FBXL2
F-box/LRR-repeat protein 2 is a protein that in humans is encoded by the FBXL2 gene.[3][4][5]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C (Nov 1999). "Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats". FEBS Lett. 459 (1): 75–9. PMID 10508920. doi:10.1016/S0014-5793(99)01211-9.
- ↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. PMID 10531035. doi:10.1016/S0960-9822(00)80020-2.
- 1 2 "Entrez Gene: FBXL2 F-box and leucine-rich repeat protein 2".
Further reading
- Ye J (2007). "Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus". PLoS Pathog. 3 (8): e108. PMC 1959368
. PMID 17784784. doi:10.1371/journal.ppat.0030108. - Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. PMID 10531037. doi:10.1016/S0960-9822(00)80021-4.
- Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. PMID 10945468. doi:10.1006/geno.2000.6211.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Wang C, Gale M, Keller BC, et al. (2005). "Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication". Mol. Cell. 18 (4): 425–34. PMID 15893726. doi:10.1016/j.molcel.2005.04.004.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.