FAT4
Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.[3][4]
FAT4 is associated with the Hippo signaling pathway.[5]
Clinical significance
Mutations in FAT4 are associated to Hennekam syndrome .[6]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)".
- ↑ Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. PMID 15003449. doi:10.1016/j.jmb.2004.01.026.
- ↑ Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer. 124 (4): 793–8. PMC 2667156
. PMID 19048595. doi:10.1002/ijc.23775. - ↑ Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics. 133: 1161–1167. PMID 24913602. doi:10.1007/s00439-014-1456-y.
Further reading
- Katoh Y, Katoh M (2006). "Comparative integromics on FAT1, FAT2, FAT3 and FAT4.". Int. J. Mol. Med. 18 (3): 523–8. PMID 16865240. doi:10.3892/ijmm.18.3.523.
- Caporaso N, Gu F, Chatterjee N; et al. (2009). Reitsma, Pieter H., ed. "Genome-wide and candidate gene association study of cigarette smoking behaviors.". PLoS ONE. 4 (2): e4653. PMC 2644817 . PMID 19247474. doi:10.1371/journal.pone.0004653.
- Liu Y, Blackwood DH, Caesar S, et al. (2010). "Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder". Molecular Psychiatry. 16 (1): HASH(0x11aa390). PMID 20351715. doi:10.1038/mp.2009.107.
- Need AC, Attix DK, McEvoy JM, et al. (2009). "A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB". Hum. Mol. Genet. 18 (23): 4650–61. PMC 2773267 . PMID 19734545. doi:10.1093/hmg/ddp413.
- Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. PMC 2896464 . PMID 20379614. doi:10.2119/molmed.2009.00159.
- Ballif BA, Villén J, Beausoleil SA, et al. (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200.
- Johnson AD, Kavousi M, Smith AV, et al. (2009). "Genome-wide association meta-analysis for total serum bilirubin levels". Hum. Mol. Genet. 18 (14): 2700–10. PMC 2701336 . PMID 19414484. doi:10.1093/hmg/ddp202.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
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