Epomediol

Epomediol
Clinical data


ATC code	A05BA05 (WHO)
Identifiers
IUPAC name (1s,4r,6R,7S)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane-6,7-diol
Synonyms	1,3,3-Trimethyl-2-oxabicyclo [2.2.2]octane-6,7-endo,endo-diol
CAS Number	56084-15-2
PubChem CID	115056
ChemSpider	102967
Chemical and physical data
Formula	C₁₀H₁₈O₃
Molar mass	186.248 g/mol
3D model (JSmol)	Interactive image
SMILES OC1CC2C(OC1(C)C(O)C2)(C)C

Epomediol (trade name Clesidren) is a synthetic terpenoid with choleretic effects. It has been used in the symptomatic treatment of itching due to intrahepatic cholestasis of pregnancy.^[1]^[2]^[3]

References

↑ Gonzalez MC, Iglesias J, Tiribelli C, et al. (September 1992). "Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy". J Hepatol. 16 (1-2): 241–2. PMID 1484159. doi:10.1016/S0168-8278(05)80122-9.
↑ Reyes H (December 1992). "The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy". Gastroenterol Clin North Am. 21 (4): 905–21. PMID 1478743.
↑ Reyes H, Simon FR (August 1993). "Intrahepatic cholestasis of pregnancy: an estrogen-related disease". Semin Liver Dis. 13 (3): 289–301. PMID 8235718. doi:10.1055/s-2007-1007357.

Bile and liver therapy (A05)
Bile therapy	bile acid (Chenodeoxycholic acid Cholic acid Ursodeoxycholic acid) Obeticholic acid Nicotinyl methylamide Piprozolin Hymecromone Cyclobutyrol
Liver therapy	Arginine glutamate Silymarin Citiolone Epomediol Ornithine oxoglutarate Tidiacic arginine Glycyrrhizin

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