Eosinophilic ulcer of the oral mucosa

Eosinophilic ulcer of the oral mucosa. H&E stain.

Eosinophilic ulcer of the oral mucosa (also known as eosinophilic ulcer of the tongue,^[1] Riga–Fede disease,^[1] and traumatic eosinophilic granuloma^[1]) is a condition characterized by an ulcer with an indurated and elevated border.^[2]^:803 The lesion might be tender, fast-growing and the patient often not be aware of any trauma in the area.

Definition

Traumatic eosinophilic granuloma of the tongue (TEGT) is a reactive condition that commonly occurs on the ventral tongue.

Causes

It is often associated with trauma. However, other causes are suspected, such as drugs, inherent predisposition, immune reaction, or lymphoproliferative disorder.

Differential Diagnosis

Squamous Cell Carcinoma, Pyogenic granulomas, Lesions of a chronic granulomatous disease and Mesenchymal tumors

Treatment

When the lesion is excised, recurrence often occurs. Palliative care with nonsteroidal anti-inflammatory drugs (NSAIDs) may be used, and topical steroids can be curative. If the lesion does not respond to treatment, biopsy is required.

References

1 2 3 Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
↑ James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

3. Ficarra G, Prignano F, Romagnoli P. Traumatic eosinophilic granuloma of the oral mucosa: A lymphoproliferative disorder? Oral Oncol.1997;33(5):375-379.

Oral and maxillofacial pathology (K00–K06, K11–K14, 520–525, 527–529)

Lips
Cheilitis Actinic Angular Plasma cell Cleft lip Congenital lip pit Eclabium Herpes labialis Macrocheilia Microcheilia Nasolabial cyst Sun poisoning Trumpeter's wart

Tongue
Ankyloglossia Black hairy tongue Caviar tongue Crenated tongue Cunnilingus tongue Fissured tongue Foliate papillitis Glossitis Geographic tongue Median rhomboid glossitis Transient lingual papillitis Glossoptosis Hypoglossia Lingual thyroid Macroglossia Microglossia Rhabdomyoma

Palate
Bednar's aphthae Cleft palate High-arched palate Palatal cysts of the newborn Inflammatory papillary hyperplasia Stomatitis nicotina Torus palatinus

Oral mucosa – Lining of mouth

Teeth (pulp, dentin, enamel)

Periodontium (gingiva, periodontal ligament, cementum, alveolus) – Gums and tooth-supporting structures

Periapaical, mandibular and maxillary hard tissues – Bones of jaws

Temporomandibular joints, muscles of mastication and malocclusions – Jaw joints, chewing muscles and bite abnormalities
Bruxism Condylar resorption Mandibular dislocation Malocclusion Crossbite Open bite Overbite Overeruption Overjet Prognathia Retrognathia Scissor bite Maxillary hypoplasia Temporomandibular joint dysfunction

Salivary glands

Orofacial soft tissues – Soft tissues around the mouth
Actinomycosis Angioedema Basal cell carcinoma Cutaneous sinus of dental origin Cystic hygroma Gnathophyma Ludwig's angina Macrostomia Melkersson–Rosenthal syndrome Microstomia Noma Oral Crohn's disease Orofacial granulomatosis Perioral dermatitis Pyostomatitis vegetans

Other
Eagle syndrome Hemifacial hypertrophy Facial hemiatrophy Oral manifestations of systemic disease Salivary microbiome

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