Enolase 2

ENO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesENO2, HEL-S-279, NSE, Enolase 2
External IDsMGI: 95394 HomoloGene: 74414 GeneCards: ENO2
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2026

13807

Ensembl

ENSG00000111674

ENSMUSG00000004267

UniProt

P09104
Q6FHV6

P17183

RefSeq (mRNA)

NM_001975

NM_013509
NM_001302642

RefSeq (protein)

NP_001966
NP_001966.1

NP_001289571
NP_038537

Location (UCSC)Chr 12: 6.91 – 6.92 MbChr 6: 124.76 – 124.77 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[3][4] Gamma-enolase is a phosphopyruvate hydratase.

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article

|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

  1. ↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

Utility

Neuron-specific enolase (NSE) immunostaining of a cerebellar hemangioblastoma.

Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small cell carcinomas which are neuroendocrine in origin. NSE is therefore a useful tumor marker for lung cancer patients.[5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.
  4. ↑ Online Mendelian Inheritance in Man (OMIM) Enolase 2 -131360
  5. ↑ Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS (April 2003). "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55–64. PMID 12640661. doi:10.1002/pros.10217.

Further reading

  • Oliva D, Calì L, Feo S, Giallongo A (1991). "Complete structure of the human gene encoding neuron-specific enolase.". Genomics. 10 (1): 157–65. PMID 2045099. doi:10.1016/0888-7543(91)90496-2. 
  • Craig SP, Day IN, Thompson RJ, Craig IW (1991). "Localisation of neurone-specific enolase (ENO2) to 12p13.". Cytogenet. Cell Genet. 54 (1–2): 71–3. PMID 2249478. doi:10.1159/000132960. 
  • Oliva D, Barba G, Barbieri G, et al. (1989). "Cloning, expression and sequence homologies of cDNA for human gamma enolase". Gene. 79 (2): 355–60. PMID 2792767. doi:10.1016/0378-1119(89)90217-5. 
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