Sodium calcium edetate

Sodium calcium edetate

Clinical data
Trade names	Calcium disodium versenate, others
AHFS/Drugs.com	Monograph
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	IV, IM
Drug class	chelating agent
ATC code	V03AB03 (WHO)
Identifiers
IUPAC name Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
Synonyms	edetate calcium disodium, sodium calcium edetate
CAS Number	62-33-9
PubChem CID	6093170
DrugBank	DB00974
ChemSpider	5883
Chemical and physical data
Formula	C10H12CaN2Na2O8
Molar mass	374.27 g·mol−1
3D model (JSmol)	Interactive image
SMILES C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
InChI InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4 Key:SHWNNYZBHZIQQV-UHFFFAOYSA-J

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning.^[1] This includes short term and long term lead poisoning. For lead encephalopathy it is typically used together with dimercaprol. It does not appear to be useful for tetraethyllead toxicity.^[2] It is given by slow injection into a vein or into a muscle.^[1]

Common side effects include pain at the site of injection.^[2] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.^[1] Benefits when needed in pregnancy are likely greater than the risks. Sodium calcium edetate is in the chelating agent family of medication.^[2] It is a salt of edetate with two sodium and one calcium atoms.^[3] It works by binding a number of heavy metals which allows them to leave the body in the urine.^[2]

Sodium calcium edetate came into medical use in the United States in 1953.^[2] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.^[4] In the United States a course of treatment costs 50 to 100 USD.^[5] Edetate disodium is a different formulation which does not have the same effects.^[2]

Medical uses

The primarily use is to treat lead poisoning.^[1] In lead toxicity it is an alternative to succimer.^[2]

It may also be used for plutonium toxicity.^[6]

History

Sodium calcium edetate came into medical use in the United States in 1953.^[2]

References

1. 1 2 3 4 WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Retrieved 8 January 2017. 
2. 1 2 3 4 5 6 7 8 "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Retrieved 8 January 2017. 
3. ↑ Kasture, Dr A. V. (2008). Pharmaceutical Chemistry - I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. 
4. ↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016. 
5. ↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 471. ISBN 9781284057560. 
6. ↑ Flanagan, Robert; Jones, Alison; Maynard, Robert L. (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071.