MAPK4
Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.[5][6]
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[6]
The Arabidopsis MAPK4 is important in signalling [7]
References
- 1 2 3 ENSG00000282110 GRCh38: Ensembl release 89: ENSG00000141639, ENSG00000282110 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024558 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.
- 1 2 "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
- ↑ Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, Nielsen HB, Lacy M, Austin MJ, Parker JE, Sharma SB, Klessig DF, Martienssen R, Mattsson O, Jensen AB & Mundy J (2000). "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance". Cell. 103 (7): 1111–1120. PMID 11163186. doi:10.1016/S0092-8674(00)00213-0.
External links
Further reading
- Seger R, Krebs EG (1995). "The MAPK signaling cascade". FASEB J. 9 (9): 726–35. PMID 7601337.
- Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. PMID 8607977. doi:10.1002/mrd.1080420414.
- Robinson MJ, Cobb MH (1997). "Mitogen-activated protein kinase pathways". Curr. Opin. Cell Biol. 9 (2): 180–6. PMID 9069255. doi:10.1016/S0955-0674(97)80061-0.
- Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Lett. 304 (2–3): 170–8. PMID 1319925. doi:10.1016/0014-5793(92)80612-K.
- Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Mol. Cell. Biol. 14 (12): 8202–11. PMC 359359
. PMID 7969157. - Kinet S, Bernard F, Mongellaz C, et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood. 100 (7): 2546–53. PMID 12239168. doi:10.1182/blood-2002-03-0819.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Sun M, Wei Y, Yao L, et al. (2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochem. Biophys. Res. Commun. 340 (1): 209–14. PMID 16360641. doi:10.1016/j.bbrc.2005.12.003.
- Kant S, Schumacher S, Singh MK, et al. (2007). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5". J. Biol. Chem. 281 (46): 35511–9. PMID 16973613. doi:10.1074/jbc.M606693200.
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