EPS8L1

EPS8L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2M, 2ROL
Identifiers
Aliases	EPS8L1, DRC3, EPS8R1, PP10566, EPS8 like 1
External IDs	MGI: 1914675 HomoloGene: 15767 GeneCards: EPS8L1
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • actin binding • T cell receptor binding • protein binding • cadherin binding Cellular component • ruffle membrane • extracellular exosome • protein complex • cytoplasm • cytosol Biological process • regulation of Rho protein signal transduction • Rho protein signal transduction • positive regulation of ruffle assembly • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54869	67425
Ensembl	ENSG00000131037	ENSMUSG00000006154
UniProt	Q8TE68	Q8R5F8
RefSeq (mRNA)	NM_017729 NM_133180 NM_139204	NM_001290416 NM_026146
RefSeq (protein)	NP_060199 NP_573441	NP_001277345 NP_080422
Location (UCSC)	Chr 19: 55.07 – 55.09 Mb	Chr 7: 4.46 – 4.48 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.^[3][4]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.^[4]

References

Further reading