ENTPD3
| ENTPD3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | ENTPD3, CD39L3, HB6, NTPDase-3, ectonucleoside triphosphate diphosphohydrolase 3 | ||||||
| External IDs | MGI: 1321386 HomoloGene: 68171 GeneCards: ENTPD3 | ||||||
| RNA expression pattern | |||||||
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| More reference expression data | |||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez | |||||||
| Ensembl | |||||||
| UniProt | |||||||
| RefSeq (mRNA) | |||||||
| RefSeq (protein) | |||||||
| Location (UCSC) | Chr 3: 40.39 – 40.43 Mb | Chr 9: 120.54 – 120.57 Mb | |||||
| PubMed search | [1] | [2] | |||||
| Wikidata | |||||||
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Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.[3][4]
ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.[4]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. PMID 9676430. doi:10.1006/geno.1998.5317.
- 1 2 "Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".
Further reading
- Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). "Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.". Biochem. Pharmacol. 74 (10): 1524–34. PMID 17727821. doi:10.1016/j.bcp.2007.07.033.
- Ivanenkov VV, Meller J, Kirley TL (2005). "Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling.". Biochemistry. 44 (25): 8998–9012. PMID 15966724. doi:10.1021/bi047487z.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). "Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions.". Biochemistry. 40 (13): 3943–50. PMID 11300774. doi:10.1021/bi002711f.
- Smith TM, Lewis Carl SA, Kirley TL (1999). "Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase.". Biochemistry. 38 (18): 5849–57. PMID 10231536. doi:10.1021/bi990171k.
- Smith TM, Kirley TL (1998). "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1.". Biochim. Biophys. Acta. 1386 (1): 65–78. PMID 9675246. doi:10.1016/s0167-4838(98)00063-6.
- Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.". Mamm. Genome. 8 (9): 668–72. PMID 9271669. doi:10.1007/s003359900534.
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