ENO3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2XSX

Identifiers

Aliases

ENO3, GSD13, MSE, enolase 3

External IDs

MGI: 95395 HomoloGene: 68215 GeneCards: ENO3

Gene ontology
Molecular function	• phosphopyruvate hydratase activity • metal ion binding • lyase activity • magnesium ion binding
Cellular component	• plasma membrane • phosphopyruvate hydratase complex • extracellular exosome • extracellular space • cytoplasm • cytosol • membrane
Biological process	• gluconeogenesis • glycolytic process • canonical glycolysis • substantia nigra development
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2027


13808

Ensembl


ENSG00000108515


ENSMUSG00000060600

UniProt


P13929


P21550

RefSeq (mRNA)


NM_001193503 NM_001976 NM_053013


NM_001136062 NM_001276285 NM_007933

RefSeq (protein)


NP_001180432 NP_001967 NP_443739


NP_001129534 NP_001263214 NP_031959

Location (UCSC)

Chr 17: 4.95 – 4.96 Mb

Chr 11: 70.66 – 70.66 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Enolase 3 (ENO3), more commonly known as beta-enolase (ENO-β), is an enzyme that in humans is encoded by the ENO3 gene.

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]^[3]

Structure

ENO3 is one of three enolase isoforms, the other two being ENO1 (ENO-α) and ENO2 (ENO-γ).^[4]^[5] Each isoform is a protein subunit that can form hetero- or homodimers of the following combinations: αα, αβ, αγ, ββ, and γγ.^[6]^[7]^[8]

Gene

The ENO3 gene spans 6 kb and contains 12 exons, though the first exon is an untranslated region and, thus, non-coding. This first intron, along with the 5'-flanking region, contains a consensus sequence for muscle-specific regulatory factors that includes a CC(A + T-rich)6GG box, a M-CAT-box CAATCCT, and two myocyte-specific enhancer-binding factor 1 boxes.^[5]^[8] Upstream of the first exon lies a TATA-like box and CpG-rich region, which contains recognition motifs for binding transcriptional regulatory factors such as Sp1, activator protein 1 and 2, CCAAT box transcription factor/nuclear factor I, and cyclic AMP.^[5] Unlike the other enolase genes, which possess multiple transcription initiation sites, ENO3 possesses a single initiation site located 26 bp downstream of the TATA-like box.^[8]

Protein

This gene encodes a 433-residue dimeric protein.^[5] Due to its comparatively small length and highly conserved intron/exon organization among the three enolase isoforms, ENO3 is suggested to have been the last to diverge from a common ancestral gene.^[8]

Function

As an enolase, ENO3 is a glycolytic enzyme that catalyzes the reversible conversion of 2-phosphoglycerate to phosphoenolpyruvate.^[5]^[6] This particular isoform is predominantly expressed in adult striated muscle, including skeletal and cardiac muscle.^[4]^[5]^[8] During fetal muscle development, there is a transcriptional switch from expressing ENO1 to ENO3 influenced by muscle innervation and Myo D1.^[5]^[8] ENO3 is expressed at higher levels in fast-twitch fibers than in slow-twitch fibers.^[8]

Clinical significance

ENO3 has been associated with energy metabolism in cancer cells. TFG-TEC, an oncoprotein, activates ENO3 expression by altering the chromatin structure of the ENO3 promoter and increasing the acetylation of histone H3.^[6]

Muscle β-enolase deficiency is a rare inherited metabolic myopathy caused by a defect in the enzyme's active site, thus disrupting its glycolytic activity. Though this deficiency is characterized as an autosomal recessive condition, both heterozygous and homozygous mutations were identified in the ENO3 gene. The heterozygous mutations were linked to milder symptoms while the homozygous mutations tended to produce more severe symptoms, including rhabdomyolysis. Advances in genetic testing, such as exome sequencing and specific gene panels, can provide greater access to diagnoses for muscle β-enolase deficiency and other rare disorders.^[7]

Interactions

TFG-TEC binds to the proximal promoter region of the ENO3 gene.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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Glycolysis and Gluconeogenesis edit

↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "ENO3 enolase 3 (beta, muscle)". NCBI Entrez Gene database.
1 2 Zhu X, Miao X, Wu Y, Li C, Guo Y, Liu Y, Chen Y, Lu X, Wang Y, He S (Jul 2015). "ENO1 promotes tumor proliferation and cell adhesion mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphomas". Experimental Cell Research. 335 (2): 216–23. PMID 26024773. doi:10.1016/j.yexcr.2015.05.020.
1 2 3 4 5 6 7 Peshavaria M, Day IN (Apr 1991). "Molecular structure of the human muscle-specific enolase gene (ENO3)". The Biochemical Journal. 275 (2): 427–33. PMC 1150071 . PMID 1840492. doi:10.1042/bj2750427.
1 2 3 4 Kim AY, Lim B, Choi J, Kim J (Aug 2015). "The TFG-TEC oncoprotein induces transcriptional activation of the human β-enolase gene via chromatin modification of the promoter region". Molecular Carcinogenesis. PMID 26310886. doi:10.1002/mc.22384.
1 2 Musumeci O, Brady S, Rodolico C, Ciranni A, Montagnese F, Aguennouz M, Kirk R, Allen E, Godfrey R, Romeo S, Murphy E, Rahman S, Quinlivan R, Toscano A (Dec 2014). "Recurrent rhabdomyolysis due to muscle β-enolase deficiency: very rare or underestimated?". Journal of Neurology. 261 (12): 2424–8. PMID 25267339. doi:10.1007/s00415-014-7512-7.
1 2 3 4 5 6 7 Giallongo A, Venturella S, Oliva D, Barbieri G, Rubino P, Feo S (Jun 1993). "Structural features of the human gene for muscle-specific enolase. Differential splicing in the 5'-untranslated sequence generates two forms of mRNA". European Journal of Biochemistry / FEBS. 214 (2): 367–74. PMID 8513787. doi:10.1111/j.1432-1033.1993.tb17932.x.