EML4

EML4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4CGC

Identifiers

EML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4

External IDs

MGI: 1926048 HomoloGene: 56841 GeneCards: EML4

Gene ontology
Molecular function	• microtubule binding
Cellular component	• cytoplasm • microtubule • cytoskeleton • membrane • microtubule cytoskeleton
Biological process	• microtubule-based process • mitotic cell cycle
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


27436


78798


ENSG00000143924


ENSMUSG00000032624


Q9HC35


Q3UMY5

RefSeq (mRNA)


NM_001145076 NM_019063


NM_001114361 NM_001114362 NM_001286567 NM_199466

RefSeq (protein)


NP_001138548 NP_061936


NP_001107833 NP_001107834 NP_001273496 NP_955760

Location (UCSC)

Chr 2: 42.17 – 42.33 Mb

Chr 17: 83.35 – 83.48 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.^[3]

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
↑ Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. PMID 18593892. doi:10.1158/0008-5472.CAN-07-6158.

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.
Heidebrecht HJ, Buck F, Pollmann M, et al. (2000). "Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein.". Genomics. 68 (3): 348–50. PMID 10995578. doi:10.1006/geno.2000.6301.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. PMID 15592455. doi:10.1038/nbt1046.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
Pollmann M, Parwaresch R, Adam-Klages S, et al. (2006). "Human EML4, a novel member of the EMAP family, is essential for microtubule formation.". Exp. Cell Res. 312 (17): 3241–51. PMID 16890222. doi:10.1016/j.yexcr.2006.06.035.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

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