EMILIN1

EMILIN1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2KA3, 2OII

Identifiers

EMILIN1, EMI, EMILIN, gp115, elastin microfibril interfacer 1

External IDs

MGI: 1926189 HomoloGene: 5117 GeneCards: EMILIN1

Gene ontology
Molecular function	• protein binding • extracellular matrix constituent conferring elasticity • identical protein binding • integrin binding involved in cell-matrix adhesion
Cellular component	• collagen trimer • proteinaceous extracellular matrix • extracellular region • extracellular exosome • extracellular space • extracellular matrix • integrin alpha4-beta1 complex • EMILIN complex
Biological process	• cell adhesion • cell-matrix adhesion • cell migration • protein homotrimerization
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


11117


100952


ENSG00000138080


ENSMUSG00000029163


Q9Y6C2


Q99K41

RefSeq (mRNA)


NM_007046


NM_133918

RefSeq (protein)


NP_008977


NP_598679

Location (UCSC)

Chr 2: 27.08 – 27.09 Mb

Chr 5: 30.91 – 30.92 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene.^[3] It is the best characterized member of the EMILIN family of extracellular matrix glycoproteins.

References

Further reading

Doliana R, Mongiat M, Bucciotti F, et al. (1999). "EMILIN, a component of the elastic fiber and a new member of the C1q/tumor necrosis factor superfamily of proteins". J. Biol. Chem. 274 (24): 16773–81. PMID 10358019. doi:10.1074/jbc.274.24.16773.
Doliana R, Canton A, Bucciotti F, et al. (2000). "Structure, chromosomal localization, and promoter analysis of the human elastin microfibril interfase located proteIN (EMILIN) gene". J. Biol. Chem. 275 (2): 785–92. PMID 10625608. doi:10.1074/jbc.275.2.785.
Mongiat M, Mungiguerra G, Bot S, et al. (2000). "Self-assembly and supramolecular organization of EMILIN". J. Biol. Chem. 275 (33): 25471–80. PMID 10821830. doi:10.1074/jbc.M001426200.
Sterzel RB, Hartner A, Schlötzer-Schrehardt U, et al. (2000). "Elastic fiber proteins in the glomerular mesangium in vivo and in cell culture". Kidney Int. 58 (4): 1588–602. PMID 11012893. doi:10.1046/j.1523-1755.2000.00320.x.
Doliana R, Bot S, Mungiguerra G, et al. (2001). "Isolation and characterization of EMILIN-2, a new component of the growing EMILINs family and a member of the EMI domain-containing superfamily". J. Biol. Chem. 276 (15): 12003–11. PMID 11278945. doi:10.1074/jbc.M011591200.
Spessotto P, Cervi M, Mucignat MT, et al. (2003). "beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain". J. Biol. Chem. 278 (8): 6160–7. PMID 12456677. doi:10.1074/jbc.M208322200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Verdone G, Colebrooke SA, Boyd J, et al. (2004). "Sequence-specific backbone NMR assignments for the C-terminal globular domain of EMILIN-1". J. Biomol. NMR. 29 (1): 91–2. PMID 15017143. doi:10.1023/B:JNMR.0000019460.94913.6a.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. PMID 16021519. doi:10.1007/s00109-005-0676-y.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell Proteomics. 5 (2): 226–33. PMID 16263699. doi:10.1074/mcp.M500324-MCP200.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117.

External links

Connective tissue

Composition

Resident	Fibroblast Fibrocyte Reticular cell Tendon cell Adipocyte Melanocyte
Wandering cells	Mast cell Macrophage

Extracellular
matrix

Ground substance	Tissue fluid
Fibers	Collagen fibers Reticular fibers: COL3A1 Elastic fibers: Elastin Fibrillin FBN1 FBN2 FBN3 EMILIN1 Elaunin

Classification

Loose	Reticular Adipose Brown White
Dense	Dense irregular connective tissue Submucosa Dermis Dense regular connective tissue Ligament Tendon Aponeurosis

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