ELF5

ELF5
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1WWX
Identifiers
Aliases	ELF5, ESE2, E74 like ETS transcription factor 5
External IDs	HomoloGene: 7702 GeneCards: ELF5
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cytoplasm • nucleus Biological process • regulation of transcription from RNA polymerase II promoter • ectodermal cell fate commitment • negative regulation of cell differentiation • cell differentiation • ectoderm development • cell proliferation • regulation of transcription, DNA-templated • somatic stem cell population maintenance • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • mammary gland epithelial cell differentiation • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2001	n/a
Ensembl	ENSG00000135374	n/a
UniProt	Q9UKW6	n/a
RefSeq (mRNA)	NM_198381 NM_001243080 NM_001243081 NM_001422	n/a
RefSeq (protein)	NP_001230009 NP_001230010 NP_001413 NP_938195	n/a
Location (UCSC)	Chr 11: 34.48 – 34.51 Mb	n/a
PubMed search	[1]	n/a
Wikidata
View/Edit Human

E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans.^[2] In humans it is also called ESE2.

Function

The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[2]

References

Further reading

External links

• ELF5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

PDB gallery
1wwx: Solution structure of the ETS-domain of the Ets domain transcription factor