ELAV-like protein 2

ELAVL2

Identifiers

ELAVL2, HEL-N1, HELN1, HUB, ELAV like neuron-specific RNA binding protein 2, ELAV like RNA binding protein 2

External IDs

MGI: 1100887 HomoloGene: 20930 GeneCards: ELAVL2

Gene ontology
Molecular function	• protein binding • mRNA 3'-UTR binding • nucleic acid binding • RNA binding
Cellular component	• nucleoplasm
Biological process	• regulation of transcription, DNA-templated • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


1993


15569


ENSG00000107105


ENSMUSG00000008489


Q12926


Q60899

RefSeq (mRNA)


NM_001171195 NM_001171197 NM_004432


NM_001177883 NM_010486 NM_207685 NM_207686 NM_001347149

RefSeq (protein)

NP_001164666 NP_001164668 NP_004423 NP_001338384 NP_001338385
NP_001338386 NP_001338387 NP_001338388 NP_001338389 NP_001338390 NP_001338391 NP_001338392 NP_001338393 NP_001338394 NP_001338395 NP_001338396 NP_001338397 NP_001338398 NP_001338399 NP_001338400 NP_001338401 NP_001338402 NP_001338403 NP_001338404 NP_001338405 NP_001338406 NP_001338407


NP_001171354 NP_001334078 NP_034616 NP_997568 NP_997569

Location (UCSC)

Chr 9: 23.69 – 23.83 Mb

Chr 4: 91.25 – 91.4 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

ELAV-like protein 2 is a protein that in humans is encoded by the ELAVL2 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Han J, Knops JF, Longshore JW, King PH (Feb 1997). "Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization". Genomics. 36 (1): 189–91. PMID 8812435. doi:10.1006/geno.1996.0444.
↑ "Entrez Gene: ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)".

Further reading

Gao FB, Carson CC, Levine T, Keene JD (1994). "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11207–11. PMC 45196 . PMID 7972035. doi:10.1073/pnas.91.23.11207.
King PH, Levine TD, Fremeau RT, Keene JD (1994). "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.". J. Neurosci. 14 (4): 1943–52. PMID 8158249.
Gao FB, Keene JD (1997). "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.". J. Cell. Sci. 109 (3): 579–89. PMID 8907704.
Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. PMC 85909 . PMID 10848602. doi:10.1128/MCB.20.13.4765-4772.2000.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature. 429 (6990): 369–74. PMC 2734081 . PMID 15164053. doi:10.1038/nature02465.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Yano M, Okano HJ, Okano H (2005). "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.". J. Biol. Chem. 280 (13): 12690–9. PMID 15671036. doi:10.1074/jbc.M411119200.

PDB gallery

1d8z: SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC)

1d9a: SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN (RBD2) OF HU ANTIGEN C (HUC)

1fnx: SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT

1fxl: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE C-FOS RNA

1g2e: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.