EGOT (gene)

EGOT
Identifiers
AliasesEGOT, EGO, NCRNA00190, eosinophil granule ontogeny transcript (non-protein coding)
External IDsGeneCards: EGOT
Orthologs
SpeciesHumanMouse
Entrez

100126791

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Ensembl

ENSG00000235947

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)Chr 3: 4.75 – 4.75 Mbn/a
PubMed search[1]n/a
Wikidata
View/Edit Human

EGOT, also known as Eosinophil Granule Ontogeny (EGO)† Transcript (non-protein coding),[2] is a human gene at 3p26.1 that produces a long noncoding RNA molecule. EGOT is nested within an intron of the inositol triphosphate receptor type 1 (ITPR1) gene. The EGOT transcript is expressed during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.[2] Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.[3]

†Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. 1 2 Wagner LA, Christensen CJ, Dunn DM, et al. (June 2007). "EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression". Blood. 109 (12): 5191–8. PMC 1890841 Freely accessible. PMID 17351112. doi:10.1182/blood-2006-06-027987.
  3. ↑ Rose D, Stadler PF (October 2011). "Molecular evolution of the non-coding eosinophil granule ontogeny transcript". Front Genet. 2. PMC 3268622 Freely accessible. PMID 22303364. doi:10.3389/fgene.2011.00069.
  4. ↑ Wright, MW (Apr 9, 2014). "A short guide to long non-coding RNA gene nomenclature.". Human genomics. 8: 7. PMC 4021045 Freely accessible. PMID 24716852. doi:10.1186/1479-7364-8-7.
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