EFCBP2

NECAB2
Identifiers
Aliases	NECAB2, EFCBP2, N-terminal EF-hand calcium binding protein 2, stip-2
External IDs	MGI: 2152211 HomoloGene: 62200 GeneCards: NECAB2
Gene ontology Molecular function • metal ion binding • protein binding • calcium ion binding • A2A adenosine receptor binding • type 5 metabotropic glutamate receptor binding • identical protein binding Cellular component • cytoplasm • plasma membrane • membrane • axon • dendrite • cell projection Biological process • positive regulation of adenosine receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of glutamate receptor signaling pathway • negative regulation of G-protein coupled receptor internalization • positive regulation of protein localization to membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54550	117148
Ensembl	ENSG00000103154	ENSMUSG00000031837
UniProt	Q7Z6G3	Q91ZP9
RefSeq (mRNA)	NM_019065 NM_001329748 NM_001329749	NM_054095
RefSeq (protein)	NP_001316677 NP_001316678 NP_061938	NP_473436
Location (UCSC)	Chr 16: 83.97 – 84 Mb	Chr 8: 119.45 – 119.47 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene.^[3][4]

Model organisms

Model organisms have been used in the study of NECAB2 function. A conditional knockout mouse line, called Necab2^{tm1a(KOMP)Wtsi[9][10]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[7][14] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.^[7]

References

Further reading