EDF1

EDF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEDF1, EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDsMGI: 1891227 HomoloGene: 2809 GeneCards: EDF1
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8721

59022

Ensembl

ENSG00000107223

ENSMUSG00000015092

UniProt

O60869

Q9JMG1

RefSeq (mRNA)

NM_153200
NM_001281297
NM_001281298
NM_001281299
NM_003792

NM_021519

RefSeq (protein)

NP_001268226
NP_001268227
NP_001268228
NP_003783
NP_694880

NP_067494

Location (UCSC)Chr 9: 136.86 – 136.87 MbChr 2: 25.56 – 25.56 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[3][4][5]

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[5]

Interactions

EDF1 has been shown to interact with:

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. PMID 9813014. doi:10.1074/jbc.273.47.31119.
  4. ↑ Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. PMID 15112053. doi:10.1007/s00018-004-4016-0.
  5. 1 2 "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
  6. 1 2 3 Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. PMID 12040021. doi:10.1210/mend.16.6.0843.
  7. ↑ Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. PMID 10816571. doi:10.1074/jbc.M001928200.
  8. ↑ Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. PMID 10567391. doi:10.1074/jbc.274.48.34196.

Further reading

  • Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1". Mol. Cell. Biol. 14 (5): 3013–21. PMC 358669 Freely accessible. PMID 8164657. 
  • Ozaki J, Takemaru KI, Ikegami T, Mishima M, Ueda H, Hirose S, Kabe Y, Handa H, Shirakawa M (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1". Genes Cells. 4 (7): 415–24. PMID 10469174. doi:10.1046/j.1365-2443.1999.00267.x. 
  • Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. PMID 10816571. doi:10.1074/jbc.M001928200. 
  • Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. PMID 12040021. doi:10.1210/mend.16.6.0843. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Bolognese F, Pitarque-Martì M, Lo Cicero V, Mantovani R, Maier JA (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription". Gene. 374: 87–95. PMID 16567061. doi:10.1016/j.gene.2006.01.030. 


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