Membrane dipeptidase
| Membrane dipeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.13.19 | ||||||||
| CAS number | 9031-99-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Membrane dipeptidase (EC 3.4.13.19, renal dipeptidase, dehydropeptidase I (DPH I), dipeptidase, aminodipeptidase, dipeptide hydrolase, dipeptidyl hydrolase, nonspecific dipeptidase, glycosyl-phosphatidylinositol-anchored renal dipeptidase, MBD, MDP, leukotriene D4 hydrolase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of dipeptides (e.g., leukotriene D4, cystinyl-bis-glycine, some β-lactam antibiotics (e.g., carbapenem))
This membrane-bound, zinc enzyme has broad specificity.
Inhibitors include bestatin and cilastatin.
Genes
- Dipeptidase 1 (DPEP1)
- Dipeptidase 2 (DPEP2)
- Dipeptidase 3 (DPEP3)
References
- ↑ Campbell, B.; Lin, H.; Davis, R.; Ballew, E. (1966). "The purification and properties of a particulate renal dipeptidase". Biochim. Biophys. Acta. 118 (2): 371–386. PMID 5961612. doi:10.1016/s0926-6593(66)80046-2.
- ↑ Campbell, B.J. (1970). "Renal dipeptidase". Methods Enzymol. 19: 722–729. doi:10.1016/0076-6879(70)19059-8.
- ↑ Kropp, H.; Sundelof, J.G.; Hajdu, R.; Kahan, F.M. (1982). "Metabolism of thienamycin and related carbapenem antibiotics by renal dipeptidase, dehydropeptidase-I". Antimicrob. Agents Chemother. 22 (1): 62–70. PMC 183675
. PMID 7125632. doi:10.1128/aac.22.1.62. - ↑ Hooper, N.M.; Keen, J.N.; Turner, A.J. (1990). "Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme". Biochem. J. 265 (2): 429–433. PMC 1136904 . PMID 2137335. doi:10.1042/bj2650429.
External links
- Membrane dipeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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