EAF1

Identifiers

EAF1, ELL associated factor 1

External IDs

Gene ontology
Molecular function	• protein binding
Cellular component	• Cajal body • nuclear speck • transcription elongation factor complex • ELL-EAF complex • intracellular membrane-bounded organelle • intercellular bridge • nucleus • nucleoplasm • nuclear body
Biological process	• regulation of transcription, DNA-templated • transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


85403


74427


ENSG00000144597


ENSMUSG00000021890


Q96JC9


Q9D4C5

RefSeq (mRNA)


NM_033083


NM_028932

RefSeq (protein)


NP_149074


NP_083208

Location (UCSC)

PubMed search

^[1]

^[2]

ELL-associated factor 1 is a protein that in humans is encoded by the EAF1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein". Blood. 98 (1): 201–9. PMID 11418481. doi:10.1182/blood.V98.1.201.
↑ "Entrez Gene: EAF1 ELL associated factor 1".

Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003). "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia". Molecular Biology of the Cell. 14 (4): 1517–28. PMC 153119 . PMID 12686606. doi:10.1091/mbc.E02-07-0394.
Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proceedings of the National Academy of Sciences of the United States of America. 102 (29): 10094–8. PMC 1177379 . PMID 16006523. doi:10.1073/pnas.0503017102.
Xiao W, Jiang F, Wang Z (January 2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". The Prostate. 66 (1): 1–12. PMID 16114057. doi:10.1002/pros.20309.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Jiang F, Ai J, Xiao W, Wang Z (August 2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Letters. 253 (2): 265–72. PMC 1989770 . PMID 17395368. doi:10.1016/j.canlet.2007.02.003.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.