Duchess of Newcastle
The Duchess of Newcastle or the Duchess of Newcastle-upon-Tyne usually refers to the wife or widow of a Duke of Newcastle, such as:
- Margaret Cavendish, Duchess of Newcastle-upon-Tyne (1623–1673), English aristocrat, writer and scientist
- Margaret Holles, Duchess of Newcastle-upon-Tyne (1623–1716), member of the Cavendish family
- Harriet Pelham-Holles, Duchess of Newcastle-upon-Tyne (1701–1776), wife of Thomas Pelham-Holles, 1st Duke of Newcastle
- Kathleen Pelham-Clinton, Duchess of Newcastle (1872–1955), conformation show judge and dog breeder
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