Alcohol abuse

Alcohol abuse
"The Drunkard’s Progress", 1846
Classification and external resources
Specialty psychiatry
ICD-10 F10.1
ICD-9-CM 305.0
MeSH D000437

Alcohol abuse is a previous psychiatric diagnosis in which there is recurring harmful use of ethanol despite its negative consequences.[1] In 2013 it was reclassified as alcohol use disorder (alcoholism) along with alcohol dependence.[2] There are two types of alcohol abuse, those who have anti-social and pleasure-seeking tendencies, and those who are anxiety-ridden people who are able to go without drinking for long periods of time but are unable to control themselves once they start.[3] Binge drinking is another form of alcohol abuse. According to surveys, the heaviest drinkers are the United Kingdom's adolescents.[4] In 2013, 139,000 deaths globally were directly due to alcohol abuse[5] and an additional 384,000 to cirrhosis from excess alcohol consumption.[5]

Definitions

Alcohol abuse is a pattern of drinking that results in harm to one’s health, interpersonal relationships, or ability to work. According to Gelder, Mayou & Geddes (2005) alcohol abuse is linked with suicide. They state the risk of suicide is high in older men who have a history of drinking, as well as those suffering from depression. Certain manifestations of alcohol abuse include failure to fulfill responsibilities at work, school, or home; drinking in dangerous situations, including the operation of a motor vehicle; legal concerns associated with alcohol use; and continued drinking despite problems that are caused or worsened by drinking. Alcohol abuse can lead to alcohol dependence.[6] In the diagnosis manual DSM-5 alcohol abuse is combined with alcohol dependence to create one unified disorder, alcohol use disorder (AUD),[7] that includes a graded clinical severity from moderate to severe with at least 2 criteria to make diagnoses. For adolescents, the DSM-5 proposes that diagnoses meeting 2 or 3 criteria would be similar to alcohol abuse while meeting over 4 criteria would be equivalent to alcohol dependence when compared to the DSM-IV.

Alcohol abuse has both short-term and long-term risks. If a person drives while drunk or regularly consuming binge drink (more than five standard drinks in one drinking session), they are considered to have been involved in alcohol abuse. Short-term abuses of alcohol include, but are not limited to, violence, injuries, unprotected sexual activities and, additionally, social and financial problems.[8]

The older adult population (over 65 years) is frequently overlooked when discussing alcohol abuse. A smaller volume of consumed alcohol has a greater impact on the older adult than it does on a younger individual. As a result, the American Geriatrics Society recommends for an older adult with no known risk factors less than one drink a day or fewer than two drinks per occasion regardless of gender,[9][10][11] this is less than current recommendations of maximum alcohol consumption per week, for adults noted to be nine drinks for a male and seven for a female.[12]

Binge drinking

In the USA, binge drinking is defined as consuming more than five units in men and four units in women. It increases chances for vandalism, fights, violent behaviours, injuries, drunk driving, trouble with police, negative health, social, economic, or legal consequences to occur.[13] Binge drinking is also associated with neurocognitive deficits of frontal lobe processing and impaired working memory as well as delayed auditory and verbal memory deficits.[13]

Binge drinking combined with the stress of returning to work is a contributing factor to Monday deaths from heart attacks.[14] The chances of becoming dependent are increased greatly in men who have 15 or more drinks each week or women who have 12 or more drinks each week. This is known as alcohol dependency.[15]

It is believed that one way to prevent binge drinking is to raise the legal drinking age.[16]

Signs and symptoms

Individuals with an alcohol use disorder will often complain of difficulty with interpersonal relationships, problems at work or school, and legal problems. Additionally, people may complain of irritability and insomnia. Alcohol abuse is also an important cause of chronic fatigue.[17]

Signs of alcohol abuse are related to alcohol's effects on organ systems. However, while these findings are often present, they are not necessary to make a diagnosis of alcohol abuse. Signs of alcohol abuse show its drastic effects on the central nervous system, including inebriation and poor judgment; chronic anxiety, irritability, and insomnia. Alcohol's effects on the liver include elevated liver function tests (classically AST is at least twice as high as ALT). Prolonged use leads to cirrhosis and liver failure. With cirrhosis, patients develop an inability to process hormones and toxins. The skin of a patient with alcoholic cirrhosis can feature cherry angiomas, palmar erythema and — in acute liver failure — jaundice and ascites. The derangements of the endocrine system lead to the enlargement of the male breasts. The inability to process toxins leads to liver disease, such as hepatic encephalopathy.

Alcohol abuse can result in brain damage which causes impairments in executive functioning such as impairments to working memory, visuospatial skills, and can cause an abnormal personality as well as affective disorders to develop.[18][19] Binge drinking is associated with individuals reporting fair to poor health compared to non-binge drinking individuals and which may progressively worsen over time. Alcohol also causes impairment in a person's critical thinking. A person's ability to reason in stressful situations is compromised, and they seem very inattentive to what is going on around them.[13] Social skills are significantly impaired in people suffering from alcoholism due to the neurotoxic effects of alcohol on the brain, especially the prefrontal cortex area of the brain. The social skills that are impaired by alcohol abuse include impairments in perceiving facial emotions, difficulty with perceiving vocal emotions and theory of mind deficits; the ability to understand humour is also impaired in alcohol abusers.[20] Adolescent binge drinkers are most sensitive to damaging neurocognitive functions especially executive functions and memory.[21] People who abuse alcohol are less likely to survive critical illness with a higher risk for having sepsis and were more likely to die during hospitalization.[22]

Violence

Alcohol abuse is significantly associated with suicide and violence. Alcohol is the most significant health concern in Native American communities because of very high rates of alcohol dependence and abuse; up to 80 percent of suicides and 60 percent of violent acts are a result of alcohol abuse in Native American communities.[23]

Pregnancy

A label on alcoholic drinks promoting zero alcohol during pregnancy

Alcohol abuse among pregnant women causes their baby to develop fetal alcohol syndrome. Fetal alcohol syndrome is the pattern of physical abnormalities and the impairment of mental development which is seen with increasing frequency among children with alcoholic mothers.[24] Alcohol exposure in a developing fetus can result in slowed development of the fetal brain, resulting in severe retardation or death. Surviving infants may suffer severe abnormalities such as abnormal eyes, fissures, lips and incomplete cerebella. Some infants may develop lung disease. It is even possible that the baby throughout pregnancy will develop heart defects such as ventricular septal defect or atrial septal defect.[25] Experts suggest that pregnant women take no more than one unit of alcohol per day. However, other organizations advise complete abstinence from alcohol while pregnant.[26]

Adolescence

Adolescence and the onset of puberty have both a physiological and social impact on a developing person. About half of grade 12 students have been drunk, and a third binge drink. About 3% drink every day.[27] One of these social impacts is the increase in risk-taking behaviors, such as the emergence of alcohol use.[28] Children aged 16 and under who consume alcohol heavily display symptoms of conduct disorder. Its symptoms include troublesome behaviour in school, constantly lying, learning disabilities and social impairments.[4]

Alcohol abuse during adolescence greatly increases the risk of developing an alcohol use disorder in adulthood due to changes to neurocircuitry that alcohol abuse causes in the vulnerable adolescent brain.[29] Younger ages of initial consumption among males in recent studies has shown to be associated with increased rates of alcohol abuse within the general population.[30]

Societal inequalities (among other factors) have influenced an adolescents decision to consume alcohol. One study suggests that girls were scrutinized for "drinking like men," whereas magazines that target the male population sent underlying messages to boys and or men that drinking alcohol was "masculine." (Bogren, 2010)[31]

Causes

The cause of alcohol abuse is complex. Alcohol abuse is related to economic and biological origins and is associated with adverse health consequences.[4] Peer pressure influences individuals to abuse alcohol; however, most of the influence of peers is due to inaccurate perceptions of the risks of alcohol abuse.[32] According to Gelder, Mayou and Geddes (2005) easy accessibility of alcohol is one of the reasons people engage in alcohol abuse as this substance is easily obtained in shops. Another influencing factor among adolescents and college students are the perceptions of social norms for drinking; people will often drink more to keep up with their peers, as they believe their peers drink more than they actually do. They might also expect to drink more given the context (e.g. sporting event, fraternity party, etc.).[33] This perception of norms results in higher alcohol consumption than is normal. Alcohol abuse is also associated with acculturation, because social and cultural factors such as an ethnic group’s norms and attitudes can influence alcohol abuse.[34]

Mental illness

A person misusing alcohol may be doing so because they find alcohol's effects provide relief from a psychological problem, such as anxiety or depression. Often both the alcohol misuse and psychological problems need to be treated at the same time.

The numbing effects of alcohol and narcotics can become a coping strategy for traumatized people who are unable to dissociate themselves from the trauma. However, the altered or intoxicated state of the abuser prevents the full consciousness necessary for healing.[35]

Puberty

Gender differences may affect drinking patterns and the risk for developing alcohol use disorders.[36] Sensation-seeking behaviors have been previously shown to be associated with advanced pubertal maturation, as well as the company of deviant peers.[28] Early pubertal maturation, as indicated by advanced morphological and hormonal development, has been linked to increased alcohol usage in both male and female individuals.[37] Additionally, when controlling for age, this association between advanced development and alcohol use still held true.[38]

Mechanisms

Excessive alcohol use causes neuroinflammation and leads to myelin disruptions and white matter loss. The developing adolescent brain is at increased risk of brain damage and other long-lasting alterations to the brain.[39] Adolescents with an alcohol use disorder damage the hippocampal, prefrontal cortex, and temporal lobes.[29]

Until recently, the underlying mechanisms mediating the link between pubertal maturation and increased alcohol use in adolescence was poorly understood. Now research has suggested that sex steroid hormone levels may play a role in this interaction. When controlling for age, it was demonstrated that elevated estradiol and testosterone levels in male teenagers undergoing pubertal development was linked to increased alcohol consumption.[40] It has been suggested that sex hormones promote alcohol consumption behaviors in teens by stimulating areas in the male adolescent brain associated with reward processing. The same associations with hormone levels were not demonstrated in females undergoing pubertal development. It is hypothesized that sex steroid hormones, such as testosterone and estradiol, are stimulating areas in the male brain that function to promote sensation-seeking and status-seeking behaviors and result in increased alcohol usage.[40] Additionally, the enzyme TTTan aromatase, which functions in the male brain to convert testosterone to estradiols, has been linked to addictive and reward-seeking behaviors. Therefore, the increased activity of the enzyme may be influencing male adolescent alcohol-usage behaviors during pubertal development.[41] The underlying mechanisms for female alcohol consumption and abuse is still under examination, but is believed to be largely influenced by morphological, rather than hormonal, changes during puberty as well as the presence of deviant peer groups.[37]

The brain goes through dynamic changes during adolescence as a result of advancing pubertal maturation, and alcohol can damage long- and short-term growth processes in teenagers.[42] The rapid effect of drugs releases the neurotransmitter dopamine which acts as reinforcement for the behavior.[3]

Diagnosis

The CAGE questionnaire may be used to screen for alcohol misuse. The CAGE questionnaire consists of four questions: "Have you ever felt the need to cut down on drinking?", "Have you ever felt annoyed by criticism of drinking?", "Have you ever felt guilty about drinking?", and "Have you ever taken a drink first thing in the morning as an eye opener?".[43] If two or more of the questions are positive, alcohol abuse is considered.

Prevention

The United States Navy provides informative, in-depth training on alcohol and drug abuse prevention to sailors and supervisors.

Preventing or reducing the harm has been called for via increased taxation of alcohol, stricter regulation of alcohol advertising and the provision of brief Interventions. Brief Interventions for alcohol abuse reduce the incidence of unsafe sex, sexual violence, unplanned pregnancy and, likely, STD transmission.[44] Information and education on social norms and the harms associated with alcohol abuse delivered via the internet or face-to-face has not been found to result in any meaningful benefit in changing harmful drinking behaviours in young people.[45]

According to European law, individuals who are suffering from alcohol abuse or other related problems cannot be given a license, or if in possession of a license cannot get it renewed. This is a way to prevent individuals driving under the influence of alcohol, but does not prevent alcohol abuse per se.[46]

An individual's need for alcohol can depend on their family's alcohol use history. For instance, if it is discovered that their family history with alcohol has a strong pattern, there might be a need for education to be set in place to reduce the likelihood of reoccurrence (Powers, 2007).[47] However, studies have established that those with alcohol abuse tend to have family members who try to provide help. In many of these occasions the family members would try to help the individual to change or to help improve the individual's lifestyle.

Treatment

Youth treatment and intervention should focus on eliminating or reducing the effects of adverse childhood experiences, like childhood maltreatment, since these are common risk factors contributing to the early development of alcohol abuse.[48] Approaches like contingency management and motivational interviewing have shown to be effective means of treating substance abuse in impulsive adolescents by focusing on positive rewards and redirecting them towards healthier goals.[49] Educating youth about what is considered heavy drinking along with helping them focus on their own drinking behaviors has been shown to effectively change their perceptions of drinking and could potentially help them to avoid alcohol abuse.[50] Completely stopping the use of alcohol, or "abstinence," is the ideal goal of treatment. A strong social network and family support maybe important in achieving this goal.

Some people who abuse alcohol may be able to reduce the amount they drink, also called "drinking in moderation." If this method does not work, the person may need to try abstinence. Abstinence has been regularly achieved by many alcoholics in Alcoholics Anonymous.

Mindfulness-based intervention programs (that encourage people to be aware of their own experiences in the present moment and of emotions that arise from thoughts) can reduce the consumption of alcohol.[51][52]

Epidemiology

Alcohol abuse is said to be most common in people aged between 15 and 24 years, according to Moreira 2009.[32] However, this particular study of 7275 college students in England collected no comparative data from other age groups or countries.

Causes of alcohol abuse are complex and are likely the combination of many factors, from coping with stress to childhood development. The US Department of Health & Human Services identifies several factors influencing adolescent alcohol use, such as risk-taking, expectancies, sensitivity and tolerance, personality and psychiatric comorbidity, hereditary factors, and environmental aspects.[53] Studies show that child maltreatment such as neglect, physical, and/or sexual abuse,[48] as well as having parents with alcohol abuse problems,[54] increases the likelihood of that child developing alcohol use disorders later in life. According to Shin, Edwards, Heeren, & Amodeo (2009), underage drinking is more prevalent among teens that experienced multiple types of childhood maltreatment regardless of parental alcohol abuse, putting them at a greater risk for alcohol use disorders.[55] Genetic and environmental factors play a role in the development of alcohol use disorders, depending on age. The influence of genetic risk factors in developing alcohol use disorders increase with age[56] ranging from 28% in adolescence and 58% in adults.[57]

Prognosis

Alcohol abuse during adolescence, especially early adolescence (i.e. before age 15), may lead to long-term changes in the brain which leaves them at increased risk of alcoholism in later years; genetic factors also influence age of onset of alcohol abuse and risk of alcoholism.[58] For example, about 40 percent of those who begin drinking alcohol before age 15 develop alcohol dependence in later life, whereas only 10 percent of those who did not begin drinking until 20 years or older developed an alcohol problem in later life.[59] It is not entirely clear whether this association is causal, and some researchers have been known to disagree with this view.[60]

Alcohol use disorders often cause a wide range of cognitive impairments that result in significant impairment of the affected individual. If alcohol-induced neurotoxicity has occurred a period of abstinence for on average a year is required for the cognitive deficits of alcohol abuse to reverse.[61]

College/university students who are heavy binge drinkers (three or more times in the past two weeks) are 19 times more likely to be diagnosed with alcohol dependence, and 13 times more likely to be diagnosed with alcohol abuse compared to non-heavy episodic drinkers, though the direction of causality remains unclear. Occasional binge drinkers (one or two times in past two weeks), were found to be four times more likely to be diagnosed with alcohol abuse or dependence compared to non-heavy episodic drinkers.[13]

Society and culture

Results of the ISCD 2010 study showing that alcohol has the highest economic cost to society of all drugs considered.

The introduction of alcopops, sweet and pleasantly flavoured alcoholic drinks, was responsible for half of the increase in alcohol abuse in 15- and 16-year-olds, according to one survey in Sweden. In the case of girls, the alcopops, which disguise the taste of alcohol, were responsible for two thirds of the increase. The introduction of alcopops to Sweden was a result of Sweden joining the European Union and adopting the entire European Union law.[62] Alcohol abuse is highly associated with adolescent suicide. Adolescents who abuse alcohol are 17 times more likely to commit suicide than adolescents who don't drink.[63]

Societal and economic costs

"After Whisky Driving Risky." Safety roadsign in Ladakh, India

Alcohol abuse is associated with many accidents, fights, driving offenses and unprotected sex. Alcohol is responsible in the world for 1.8 million deaths and results in disability in approximately 58.3 million people. Approximately 40 percent of the 58.3 million people disabled through alcohol abuse are disabled due to alcohol-related neuropsychiatric disorders.[64] In South Africa, where HIV infection is epidemic, alcohol abusers exposed themselves to double the risk of this infection. Moreover, problems caused by alcohol abuse in Ireland cost about 3.7 billion euro in 2007.[65] Additionally, alcohol abuse increases the risk of individuals either experiencing or perpetrating sexual violence.[44]

In the United States, many people are arrested for drinking and driving. Also, people under the influence of alcohol commit a large portion of various violent crimes, including child abuse, homicide and suicide. In addition, people of minority groups are affected by alcohol-related problems disproportionately, with the exception of Asian Americans.[66]

Also, according to studies of present and former alcoholic drinkers in Canada, 20% of them are aware that their drinking has negatively impacted their lives in various vital areas including finances, work and relationships.[67]

Alcohol misuse costs the United Kingdom's National Health Service £3 billion per year. The cost to employers is 6.4 billion pounds sterling per year. These figures do not include the crime and social problems associated with alcohol misuse. The number of women regularly drinking alcohol has almost caught up with men.[68]

See also

References

  1. ↑ Diagnostic and statistical manual of mental disorders : DSM-5. (Fifth edition. ed.). 2013. p. 490. ISBN 9780890425572.
  2. ↑ "Alcohol Use Disorder: A Comparison Between DSM–IV and DSM–5". November 2013. Retrieved 9 May 2015.
  3. 1 2 Neil R.Carlson, C.Donald Heth. "Psychology: The Science of Behaviour". Pearson Canada Inc,2010, p.572.
  4. 1 2 3 McArdle, Paul (27 February 2008). "Alcohol abuse in adolescents". BMJ. 93 (6): 524–527. PMID 18305075. doi:10.1136/adc.2007.115840.
  5. 1 2 GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.". Lancet. 385 (9963): 117–71. PMC 4340604 Freely accessible. PMID 25530442. doi:10.1016/S0140-6736(14)61682-2.
  6. ↑ Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th edition, Text Revision. Washington, DC: American Psychiatric Association; 2000.
  7. ↑ "Substance-Related and Addictive Disorders" (PDF). American Psychiatric Association. 2013. Archived from the original (PDF) on 15 August 2015. Retrieved 28 November 2013.
  8. ↑ Michaud, PA (Feb 2007). "Alkoholmissbrauch im Jugendalter - eine Herausforderung für Hausärzte" [Alcohol misuse in adolescents - a challenge for general practitioners]. Therapeutische Umschau (in German). 64 (2): 121–6. PMID 17245680. doi:10.1024/0040-5930.64.2.121.
  9. ↑ Dufour, MC; Archer, L; Gordis, E (1992). "Alcohol and the elderly". Clinics in geriatric medicine. 8 (1): 127–41. PMID 1576571.
  10. ↑ Moos, RH; Schutte, KK; Brennan, PL; Moos, BS (2009). "Older adults' alcohol consumption and late-life drinking problems: A 20-year perspective". Addiction (Abingdon, England). 104 (8): 1293–1302. PMC 2714873 Freely accessible. PMID 19438836. doi:10.1111/j.1360-0443.2009.02604.x.
  11. ↑ Wilson, SR; Fink, A; Verghese, S; Beck, JC; Nguyen, K; Lavori, P (2007). "Adding an alcohol-related risk score to an existing categorical risk classification for older adults: Sensitivity to group differences". Journal of the American Geriatrics Society. 55 (3): 445–50. PMID 17341250. doi:10.1111/j.1532-5415.2007.01072.x.
  12. ↑ Wallace, C; Black, Damien J; Fothergill, Anne (2010). "Integrated assessment of older adults who misuse alcohol". Nursing Standard. 24 (33): 51–58. PMID 20461924. doi:10.7748/ns2010.04.24.33.51.c7718.
  13. 1 2 3 4 Courtney, Kelly E; Polich, John (January 2009). "Binge drinking in young adults: Data, definitions, and determinants". Psychological Bulletin. 135 (1): 142–56. PMC 2748736 Freely accessible. PMID 19210057. doi:10.1037/a0014414.
  14. ↑ Phil Barker (7 October 2003). Psychiatric and mental health nursing: the craft of caring. London: Arnold. ISBN 978-0-340-81026-2. Retrieved 17 December 2010.
  15. ↑ "Alcoholism and alcohol abuse". PubMed Health. A.D.A.M., Inc. Retrieved 3 December 2012.
  16. ↑ Babor, TF.; Aguirre-Molina, M.; Marlatt, GA.; Clayton, R. (1999). "Managing alcohol problems and risky drinking". Am J Health Promot. 14 (2): 98–103. PMID 10724728. doi:10.4278/0890-1171-14.2.98.
  17. ↑ Avellaneda Fernández, A.; Pérez Martín, A.; Izquierdo Martínez, M.; Arruti Bustillo, M.; Barbado Hernández, FJ.; De La Cruz Labrado, J.; Díaz-Delgado Peñas, R.; Gutiérrez Rivas, E.; Palacín Delgado, C.; Rivera Redondo, Javier; Ramón Giménez, José Ramón (2009). "Chronic fatigue syndrome: aetiology, diagnosis and treatment". BMC Psychiatry. 9 Suppl 1: S1. PMC 2766938 Freely accessible. PMID 19857242. doi:10.1186/1471-244X-9-S1-S1.
  18. ↑ Fitzpatrick LE, Jackson M, Crowe SF (2008). "The relationship between alcoholic cerebellar degeneration and cognitive and emotional functioning". Neurosci Biobehav Rev. 32 (3): 466–85. PMID 17919727. doi:10.1016/j.neubiorev.2007.08.004.
  19. ↑ van Holst RJ, Schilt T (March 2011). "Drug-related decrease in neuropsychological functions of abstinent drug users". Curr Drug Abuse Rev. 4 (1): 42–56. PMID 21466500. doi:10.2174/1874473711104010042.
  20. ↑ Uekermann J, Daum I (May 2008). "Social cognition in alcoholism: a link to prefrontal cortex dysfunction?". Addiction. 103 (5): 726–35. PMID 18412750. doi:10.1111/j.1360-0443.2008.02157.x.
  21. ↑ Amrani, L; De Backer, L; Dom, G (2013). "Piekdrinken op jonge leeftijd: gevolgen voor neurocognitieve functies en genderverschillen" [Adolescent binge drinking: neurocognitive consequences and gender differences] (PDF). Tijdschr Psychiatr (in Dutch). 55 (9): 677–89. PMID 24046246.
  22. ↑ "Alcohol Abuse". Juvenile Justice Digest. 35 (2): 7. 2007-01-31. ISSN 0094-2413.
  23. ↑ Jiwa, A.; Kelly, L.; Pierre-Hansen, N. (Jul 2008). "Healing the community to heal the individual: literature review of aboriginal community-based alcohol and substance abuse programs". Can Fam Physician. 54 (7): 1000–1000.e7. PMC 2464791 Freely accessible. PMID 18625824.
  24. ↑ Landesman-Dwyer, S (1982). "Maternal drinking and pregnancy outcome". Applied research in mental retardation. 3 (3): 241–63. PMID 7149705. doi:10.1016/0270-3092(82)90018-2.
  25. ↑ Vorvick, Linda (August 15, 2011). "Fetal alcohol syndrome". PubMed Health. Retrieved 9 April 2012.
  26. ↑ Batra, S.; Wrigley, ECW (April 2005). "Alcohol: The teratogen". Obstetrics & Gynecology: 308–309.
  27. ↑ Tripodi, SJ; Bender, K; Litschge, C; Vaughn, MG (January 2010). "Interventions for reducing adolescent alcohol abuse: a meta-analytic review.". Archives of pediatrics & adolescent medicine. 164 (1): 85–91. PMID 20048247. doi:10.1001/archpediatrics.2009.235.
  28. 1 2 Martin, C.; Kelly, T.; Rayens, M.; Brogli, B.; Brenzel, A.; Smith, J.; Omar, O. (December 2002). "Sensation Seeking, Puberty, and Nicotine, Alcohol, and Marijuana Use in Adolescence". Journal of the American Academy of Child & Adolescent Psychiatry. 41 (12): 1495–1502. doi:10.1097/00004583-200212000-00022.
  29. 1 2 Nixon, K.; McClain, JA. (May 2010). "Adolescence as a critical window for developing an alcohol use disorder: current findings in neuroscience". Current Opinion in Psychiatry. 23 (3): 227–32. PMC 3149806 Freely accessible. PMID 20224404. doi:10.1097/YCO.0b013e32833864fe.
  30. ↑ Stewart, S.H. (May 1996). "Alcohol Abuse in Individuals Exposed to Trauma: A Critical Review". Psychological Bulletin. 120 (1): 83–112. PMID 8711018. doi:10.1037/0033-2909.120.1.83.
  31. ↑ Bogren, A (2011). "Gender and alcohol: The swedish press debate". Journal of Gender Studies.
  32. 1 2 Moreira, MT.; Smith, LA.; Foxcroft, D.; Moreira, Maria Teresa (2009). Moreira, Maria Teresa, ed. "Social norms interventions to reduce alcohol misuse in university or college students". Cochrane Database of Systematic Reviews (3): CD006748. PMID 19588402. doi:10.1002/14651858.CD006748.pub2.
  33. ↑ Lewis, MA; Litt, DM; Blayney, JA; Lostutter, TW; Granato, H; Kilmer, JR; Lee, CM (2011). "They drink how much and where? Normative perceptions by drinking contexts and their association to college students' alcohol consumption". Journal of Studies on Alcohol and Drugs. 72 (5): 844–853. PMC 3174028 Freely accessible. PMID 21906511. doi:10.15288/jsad.2011.72.844.
  34. ↑ Vélez-Mcevoy, M (2005). "Alcohol abuse and ethnicity". AAOHN Journal. 53 (4): 152–155. PMID 15853289.
  35. ↑ Herman, Judith. Trauma and Recovery: The Aftermath of Violence - from domestic abuse to political terror. pp. 44–45. ISBN 978-0465087303.
  36. ↑ Witt, E. (October 2007). "Puberty, Hormones & Sex Differences in Alcohol Use and Dependence". Neurotoxicology and Teratology. 29 (1): 81–95. PMID 17174531. doi:10.1016/j.ntt.2006.10.013.
  37. 1 2 Costello, E.; Sung, M.; Worthman, C.; Angold, A. (April 2007). "Pubertal Maturation and the Development of Alcohol Use and Abuse". Drug and Alcohol Dependence. 88: S50–S59. PMID 17275214. doi:10.1016/j.drugalcdep.2006.12.009.
  38. ↑ Westling, E.; Andrews, J.; Hampson, S.; Peterson, M. (2008). "Pubertal timing and substance use: The effects of gender, parental monitoring and deviant peers". Journal of Adolescent Health. 42 (6): 555–563. PMC 2435092 Freely accessible. PMID 18486864. doi:10.1016/j.jadohealth.2007.11.002.
  39. ↑ Alfonso-Loeches, S.; Guerri, C. (2011). "Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain". Crit Rev Clin Lab Sci. 48 (1): 19–47. PMID 21657944. doi:10.3109/10408363.2011.580567.
  40. 1 2 de Waters, E.; Braams, B.; Crone, E.; Peper, J. (2013). "Pubertal Maturation and Sex Steroids are Related to Alcohol use in Adolescence". Hormones & Behavior. 63 (2): 392–397. doi:10.1016/j.yhbeh.2012.11.018.
  41. ↑ Lenz, B.; Heberlein, A.; Bayerlein, K.; Frieling, H.; Kornhuber, J.; Bleich, S.; Hillemacher, T. (2011). "The TTTan aromatase (CYP19A1) polymorphism is associated with compulsive cravings of male patients during alcohol withdrawal". Psychoneuroendocrinology. 36 (8): 1261–1264. PMID 21414724. doi:10.1016/j.psyneuen.2011.02.010.
  42. ↑ "Find Out More, Do More". Office of Substance Abuse, Maine Department of Health and Human Services. Retrieved December 27, 2012.
  43. ↑ Bickley, L.S; Szilagyi, P.G. Bate's Guide to Physical Examination and History Taking 9th ed.; Lippincott Williams & Wilkins; 2007 ISBN 9780781767187
  44. 1 2 Chersich, MF.; Rees, HV. (Jan 2010). "Causal links between binge drinking patterns, unsafe sex and HIV in South Africa: its time to intervene". Int J STD AIDS. 21 (1): 2–7. PMID 20029060. doi:10.1258/ijsa.2000.009432.
  45. ↑ Foxcroft, DR; Moreira, MT; Almeida Santimano, NM; Smith, LA (26 January 2015). "Social norms information for alcohol misuse in university and college students.". The Cochrane database of systematic reviews. 1: CD006748. PMID 25622306.
  46. ↑ Appenzeller, Brice M.R.; Schneider, Serge; Yegles, Michel; Maul, Armand; Wennig, Robert (2005). "Drugs and chronic alcohol abuse in drivers". Forensic Science International. 155 (2–3): 83–90. PMID 16226145. doi:10.1016/j.forsciint.2004.07.023.
  47. ↑ Rebecca A. (2007). "Alcohol and Drug Abuse Prevention". Psychiatric Annals. 37 (5): 349–358.
  48. 1 2 Dube, Shanta R; Anda, Robert F; Felitti, Vincent J; Edwards, Valerie J; Croft, Janet B (2002). "Adverse childhood experiences and personal alcohol abuse as an adult". Addictive Behaviors. 27 (5): 713–725. PMID 12201379. doi:10.1016/S0306-4603(01)00204-0.
  49. ↑ GULLO, M; DAWE, S (2008). "Impulsivity and adolescent substance use: Rashly dismissed as "all-bad"?". Neuroscience & Biobehavioral Reviews. 32 (8): 1507–1518. doi:10.1016/j.neubiorev.2008.06.003.
  50. ↑ Agostinelli, Gina; Grube, Joel (2005). "Effects of Presenting Heavy Drinking Norms on Adolescents? Prevalence Estimates, Evaluative Judgments, and Perceived Standards". Prevention Science. 6 (2): 89–99. PMID 15889624. doi:10.1007/s11121-005-3408-1.
  51. ↑ Chiesa A (Apr 2014). "Are mindfulness-based interventions effective for substance use disorders? A systematic review of the evidence". Subst Use Misuse. 49 (5): 492–512. PMID 23461667. doi:10.3109/10826084.2013.770027.
  52. ↑ Garland EL (Jan 2014). "Mindfulness training targets neurocognitive mechanisms of addiction at the attention-appraisal-emotion interface". Front Psychiatry. 4 (173). doi:10.3389/fpsyt.2013.00173.
  53. ↑ "Diagnostic Criteria for Alcohol Abuse and Dependence". Alcohol Alert. National Institute on Alcohol Abuse and Alcoholism (30 PH 359). October 1995. Retrieved 1 Nov 2013.
  54. ↑ Lieb, R.; Merikangas, K. R.; Höfler, M.; Pfister, H.; Isensee, B.; Wittchen, H.-U. (2002). "Parental alcohol use disorders and alcohol use and disorders in offspring: a community study". Psychological Medicine. 32 (1). doi:10.1017/S0033291701004883.
  55. ↑ Shin, Sunny Hyucksun; Edwards, Erika; Heeren, Timothy; Amodeo, Maryann (2009). "Relationship between Multiple Forms of Maltreatment by a Parent or Guardian and Adolescent Alcohol Use". American Journal on Addictions. 18 (3): 226–234. doi:10.1080/10550490902786959.
  56. ↑ Brown, S. A.; McGue, M.; Maggs, J.; Schulenberg, J.; Hingson, R.; Swartzwelder, S.; Martin, C.; Chung, T.; Tapert, S. F.; Sher, K.; Winters, K. C.; Lowman, C.; Murphy, S. (2008). "A Developmental Perspective on Alcohol and Youths 16 to 20 Years of Age|". Pediatrics. 121 (Suppl 4): S290–S310. PMC 2765460 Freely accessible. PMID 18381495. doi:10.1542/peds.2007-2243D.
  57. ↑ Beek, Jenny H. D. A.; Kendler, Kenneth S.; Moor, Marleen H. M.; Geels, Lot M.; Bartels, Meike; Vink, Jacqueline M.; Berg, Stéphanie M.; Willemsen, Gonneke; Boomsma, Dorret I. (2012). "Stable Genetic Effects on Symptoms of Alcohol Abuse and Dependence from Adolescence into Early Adulthood". Behavior Genetics. 42 (1): 40–56. doi:10.1007/s10519-011-9488-8.
  58. ↑ "Early Age At First Drink May Modify Tween/Teen Risk For Alcohol Dependence". Medical News Today. 21 September 2009.
  59. ↑ Grant, BF.; Dawson, DA. (1997). "Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey". J Subst Abuse. 9: 103–10. PMID 9494942. doi:10.1016/S0899-3289(97)90009-2.
  60. ↑ Schwandt, M.L.; Lindell, S.G.; Chen, S.; Higley, J.D.; Suomi, S.J.; Heilig, M.; Barr, C.S. (Feb 2010). "Alcohol response and consumption in adolescent rhesus macaques". Alcohol. 44 (1): 67–80. PMC 2818103 Freely accessible. PMID 20113875. doi:10.1016/j.alcohol.2009.09.034.
  61. ↑ Stavro K, Pelletier J, Potvin S (March 2013). "Widespread and sustained cognitive deficits in alcoholism: a meta-analysis". Addict Biol. 18 (2): 203–13. PMID 22264351. doi:10.1111/j.1369-1600.2011.00418.x.
  62. ↑ Romanus, G. (Dec 2000). "Alcopops in Sweden--a supply side initiative". Addiction. 95 Suppl 4 (12s4): S609–19. PMID 11218355. doi:10.1046/j.1360-0443.95.12s4.12.x.
  63. ↑ Groves, SA.; Stanley, BH.; Sher, L. (2007). "Ethnicity and the relationship between adolescent alcohol use and suicidal behavior". Int J Adolesc Med Health. 19 (1): 19–25. PMID 17458320. doi:10.1515/IJAMH.2007.19.1.19.
  64. ↑ "Global status report on alcohol and health 2014". World Health Organization. Retrieved 24 July 2017.
  65. ↑ "Alcohol and costs". AlcoholAction. Retrieved 1 December 2014.
  66. ↑ Alcoholism. (2013). Columbia Electronic Encyclopedia, 6th Edition, 1-2.
  67. ↑ "Send Us a Message." Alcoholism in Canada. Web. 03 Apr. 2012. <http://www.ledgehill.com/resources/addiction-info/alcoholism-in-canada/> Archived March 29, 2012, at the Wayback Machine..
  68. ↑ Dooldeniya, MD.; Khafagy, R.; Mashaly, H.; Browning, AJ.; Sundaram, SK.; Biyani, CS. (Nov 2007). "Lower abdominal pain in women after binge drinking". BMJ. 335 (7627): 992–3. PMC 2072017 Freely accessible. PMID 17991983. doi:10.1136/bmj.39247.454005.BE.
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