Doripenem

Doripenem
Clinical data
Trade names Finibax, Doribax
AHFS/Drugs.com Monograph
MedlinePlus a608015
License data
Pregnancy
category
  • B
Routes of
administration		 IM, IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Metabolism Renal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C15H24N4O6S2
Molar mass 420.50426 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Doripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. The usual form is doripenem monohydrate.

Doripenem can be used for bacterial infections such as: complex abdominal infections, pneumonia within the setting of a hospital, and complicated infections of the urinary tract including kidney infections with septicemia. Doripenem decreases the process of cell wall growth, which eventually leads to elimination of the infectious cell bacteria altogether.

It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem.

Doripenem was approved by the United States Food and Drug Administration on October 12, 2007, to be sold under the tradename Doribax.[1] It is the fourth member of the carbapenem class to be approved in the United States. The greater stability of doripenem in aqueous solution compared to earlier members of the carbapenem class allows it to be administered as an infusion over 4 hours or more, which may be advantageous in the treatment of certain difficult-to-treat infections.[2][3] It may present a lower risk of inducing seizures than other carbapenems.[4]

Chemistry and Pharmacology

Doripenem is a beta-lactam antibiotic agent belonging to the carbapenem group, with a broad spectrum of bacterial sensitivity including both gram-positive and gram-negative bacteria. In vivo, doripenem inhibits the synthesis of cell walls by attaching itself to penicillin-binding proteins, also known as PBPs. However it is not active against MRSA. It is stable against beta-lactamases including those with extended spectrum, but it is susceptible to the action of carbapenemases. Doripenem is also more active against Pseudomonas aeruginosa than other carbapenems.[5]

Physicochemical Properties

Doripenem appears as crystalline powder, with colour anywhere from a white to somewhat yellowish. Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also soluble in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powdered drug can form a monohydrate when mixed with water. However, doripenem has not been proven to possess polymorphism.

Adverse effects

Resistance

Potential avenues for the development of resistance to doripenem are: altered PBPs (penicillin-binding protein), reduced activity in the permeability of the outer membrane especially when accepting foreign toxic substances within the cell, and deactivation of the drug by hydrolyzing enzymes from the carbapenem. Beta-lactamases (such as penicillinases) formed by gram-positive and gram-negative bacteria can stabilize doripenem to hydrolysis. However, carbapenem-hydrolyzing beta-lactamases are an exception.

Pharmacokinetics

Distribution

On average, about 8.1% of plasma proteins attached to doripenem; it is separate from drug concentrations of plasma.[5] Doripenem’s distribution volume is close to that of extracellular fluid volume in humans (18.2 L). When doripenem is essentially stable, the average volume of distribution is approximately 16.8 L. Within the few of the body’s fluids and tissues, Doripenem is filtered successfully as well as reaching concentration levels that are able to restrain from more vulnerable bacteria than what is required.

Metabolism

Doripenem is metabolized by the enzyme dehydropeptidase-I into an inactive ring-opened metabolite.

Excretion

In young and healthy adults, the elimination half-life of doripenem considering the average plasma terminal is normally around 1 hour. The plasma clearance is about 15.9 L/hour and the average renal clearance is 10.3 L/hour. Research indicates doripenem is filtered by the glomerular capillary bed in Bowman’s capsule and the tubular secretions in the nephron.

References

  1. ↑ "FDA Approves New Drug to Treat Complicated Urinary Tract and Intra-Abdominal Infections" (Press release). U.S. Food and Drug Administration. October 17, 2007. Retrieved 2007-10-25.
  2. ↑ Mazzei, T (2010). "The pharmacokinetics and pharmacodynamics of the carbapanemes: Focus on doripenem". Journal of Chemotherapy. 22 (4): 219–25. PMID 20685624. doi:10.1179/joc.2010.22.4.219.
  3. ↑ Greer, N. D. (2008). "Doripenem (Doribax): The newest addition to the carbapenems". Proceedings (Baylor University. Medical Center). 21 (3): 337–41. PMC 2446428 Freely accessible. PMID 18628935.
  4. ↑ Zhanel, G. G.; Ketter; Rubinstein; Friedland; Redman (2009). "Overview of seizure-inducing potential of doripenem". Drug Safety. 32 (9): 709–16. PMID 19670912. doi:10.2165/00002018-200932090-00001.
  5. 1 2 "Doripenem for Injection for the Treatment of Nosocomial Pneumonia" (PDF) (Press release). Johnson & Johnson. July 16, 2008. Retrieved 2010-05-19.
  6. 1 2 3 4 http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022106s012lbl.pdf

Further reading

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