Dopamine antagonist
| Dopamine receptor antagonist Dopaminergic blockers | |
|---|---|
| Drug class | |
 Skeletal structor formula of Haloperidol, a typical antipsychotic | |
| Class identifiers | |
| Use | Schizophrenia, bipolar disorder, nausea and vomiting, etc. |
| ATC code | N05A |
| Biological target | Dopamine receptors |
| External links | |
| MeSH | D012559 |
| In Wikidata | |
A dopamine antagonist (antidopaminergic) is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis. Several other dopamine antagonists are antiemetics used in the treatment of nausea and vomiting.
Uses and examples
Dopamine receptor antagonists are used for some diseases such as schizophrenia, bipolar disorder, nausea and vomiting. It can also control the symptoms of hypersexuality and increased orgasmic activity.
Antidopaminergics such as haloperidol can be an antidote for poisoning with cocaine, amphetamines and dopamine agonists such as bromocriptine and/or ropinirole.
- Agents such as atypical antipsychotics (coupled with serotonin antagonist effects): paliperidone, clozapine, risperidone, olanzapine, quetiapine, and ziprasidone
- Used as antiemetics: metoclopramide, droperidol, domperidone
- Used as tricyclic antidepressants: amoxapine, clomipramine, trimipramine
- Choline can antagonize dopamine directly or interfere with receptor function
- Melatonin suppresses dopamine activity[1] as part of normal circadian rhythm functions, although pathological imbalances have been implicated in Parkinson's disease[2]
Side effects
They may include one or more of the following and last indefinitely even after cessation of the dopamine antagonist, especially after long-term or high-dosage use:
- Dysphoria and depression
- Extrapyramidal symptoms, including:
- Akathisia
- Parkinsonism due to effects on the nigrostriatal pathway
- Tardive dyskinesia (long-term use)
- Galactorrhea due to removal of dopamine-mediated inhibition (D2 receptor antagonism) on the lactotrophic cells in the anterior pituitary preventing the release of prolactin.
- Hyperprolactinaemia due to effects on the tuberoinfundibular pathway
- Increased appetite
- Irritability and aggression
- Low libido, sexual dysfunction and impotence due to blockage of the pleasure center (dopaminergic pathways)
- Menstrual disorder
- Metabolic changes with increased risk of obesity and diabetes mellitus type 2
- Neuroleptic Induced Deficit Syndrome (long-term use)
- Paranoia (rare)
- Sedation or psychomotor agitation
- Symptoms similar to ADHD
- Symptoms similar to narcolepsy
Examples
Examples of Dopamine antagonists include:[3]
- acepromazine
- amisulpride
- amoxapine
- asenapine
- azaperone
- benperidol
- bromopride
- butaclamol
- clomipramine (mild)
- chlorpromazine
- chlorprothixene
- clopenthixol
- domperidone
- droperidol
- eticlopride
- flupenthixol
- fluphenazine
- fluspirilene
- haloperidol
- hydroxyzine
- iodobenzamide
- levomepromazine
- loxapine
- mesoridazine
- metoclopramide
- nafadotride
- nemonapride
- olanzapine
- paliperidone
- penfluridol
- perazine
- perphenazine
- pimozide
- prochlorperazine
- promazine
- quetiapine
- raclopride
- remoxipride
- risperidone
- spiperone
- spiroxatrine
- stepholidine
- sulpiride
- sultopride
- tetrahydropalmatine
- thiethylperazine
- thioridazine
- thiothixene
- tiapride
- trifluoperazine
- trifluperidol
- triflupromazine
- ziprasidone
See also
- Dopamine agonist
- Dopaminergic
- Serotonin antagonist
- Adrenergic antagonist
- Histamine antagonist
- Acetylcholine antagonist
- GABA antagonist
References
- ↑ Zisapel, N (2001). "Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting". Cellular and Molecular Neurobiology. 21 (6): 605–16. PMID 12043836.
- ↑ Willis, GL (2008). "Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process". Reviews in the Neurosciences. 19 (4–5): 245–316. PMID 19145986. doi:10.1515/revneuro.2008.19.4-5.245.
- ↑ MeSH list of agents 82018492
External links
- Dopamine antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)