Dock5

DOCK5
Identifiers
AliasesDOCK5, Dock5, dedicator of cytokinesis 5
External IDsMGI: 2652871 HomoloGene: 57016 GeneCards: DOCK5
Orthologs
SpeciesHumanMouse
Entrez

80005

68813

Ensembl

ENSG00000147459

ENSMUSG00000044447

UniProt

Q9H7D0

B2RY04

RefSeq (mRNA)

NM_024940
NM_001322810

NM_177780

RefSeq (protein)

NP_001309739
NP_079216

NP_808448

Location (UCSC)Chr 8: 25.18 – 25.42 MbChr 14: 67.75 – 67.93 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Dock5 (Dedicator of cytokinesis 5), also known as DOCK5, is a large (~180 kDa) protein involved in intracellular signalling networks.[3] It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins.[4] Dock5 is predicted to activate the small G protein Rac.

Function

Dock5 shares significant sequence identity with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar interactions although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in osteoclasts,[5] and suppression of Dock5 expression with shRNA has been shown to inhibit survival and differentiation of osteoclast precursor cells.[6] In addition, a mutation in Dock5 has been associated with the rupture of murine lens cataracts.[7] In zebrafish Dock5 has been implicated in myoblast fusion.[8]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: DOCK5 dedicator of cytokinesis 5".
  4. ↑ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell. Sci. 115 (Pt 24): 4901–13. PMID 12432077. doi:10.1242/jcs.00219.
  5. ↑ Ha BG, Hong JM, Park JY (July 2008). "Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion". Proteomics. 8 (13): 2625–39. PMID 18600791. doi:10.1002/pmic.200701192.
  6. ↑ Brazier H, Stephens S, Ory S (September 2006). "Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts". J. Bone Min. Res. 21 (9): 1387–98. PMID 16939397. doi:10.1359/jbmr.060613.
  7. ↑ Omi N, Kiyokawa E, Matsuda M (May 2008). "Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse". Exp. Eye Res. 86 (5): 828–34. PMID 18396277. doi:10.1016/j.exer.2008.02.011.
  8. ↑ Moore CA, Parkin CA, Bidet Y, Ingham PW (September 2007). "A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion". Development. 134 (17): 3145–53. PMID 17670792. doi:10.1242/dev.001214.

Further reading


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