6',7'-Dihydroxybergamottin
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Properties | |
C21H24O6 | |
Molar mass | 372.42 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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6',7'-Dihydroxybergamottin is a natural furanocoumarin found principally in grapefruit juice.[1] Along with the chemically related compound bergamottin, it is believed to be responsible for a number of grapefruit–drug interactions, in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.[2][3]
References
- ↑ Edwards, D.J.; F.H Bellevue, 3rd; P.M. Woster (December 1996). "Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice". Drug Metabolism & Disposition. 24 (12): 1287–1290.
- ↑ David G. Bailey; J. Malcolm; O. Arnold; J. David Spence (1998). "Grapefruit juice-drug interactions". Br J Clin Pharmacol. 46 (2): 101–110. PMC 1873672 . PMID 9723817. doi:10.1046/j.1365-2125.1998.00764.x.
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