Diclofenamide

Diclofenamide
Clinical data


AHFS/Drugs.com	International Drug Names
MedlinePlus	a601233
ATC code	S01EC02 (WHO)
Pharmacokinetic data
Protein binding	55%
Identifiers
IUPAC name 4,5-Dichlorobenzene-1,3-disulfonamide
CAS Number	120-97-8^Y
PubChem CID	3038
IUPHAR/BPS	6807
DrugBank	DB01144^N
ChemSpider	2930^Y
UNII	VVJ6673MHY
KEGG	D00518^Y
ChEBI	CHEBI:101085^Y
ChEMBL	CHEMBL17^Y
ECHA InfoCard	100.004.037
Chemical and physical data
Formula	C₆H₆Cl₂N₂O₄S₂
Molar mass	305.16 g/mol
3D model (JSmol)	Interactive image
Melting point	228.5 °C (443.3 °F)
SMILES Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N
InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)^Y Key:GJQPMPFPNINLKP-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.

Uses

Diclofenamide is used to treat glaucoma^[1]^[2] and therapy-resistant epilepsy.^[3]

↑ International Drug Names: Diclofenamide
↑ Kanski, J. J. (1968). "Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British journal of ophthalmology. 52 (8): 642–643. PMC 506660 . PMID 5724852. doi:10.1136/bjo.52.8.642.
↑ Rucquoy, M.; Sorel, L. (1978). "Diclofenamide in the treatment of therapy-resistant epilepsy". Acta Neurologica Belgica. 78 (3): 174–182. PMID 352085.

Drugs used for glaucoma preparations and miosis (S01E)

muscarinic	Aceclidine Pilocarpine
muscarinic/nicotinic	Acetylcholine Carbachol
acetylcholinesterase inhibitors	Demecarium Ecothiopate Stigmine (Fluostigmine Neostigmine Physostigmine) Paraoxon

Other agents

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