Dichlorochromopyrrolate synthase
| Dichlorochromopyrrolate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.21.3.9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Dichlorochromopyrrolate synthase (EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming).[1][2] This enzyme catalyses the following chemical reaction
- 4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O
This enzyme catalyses a step in the biosynthesis of rebeccamycin.
References
- ↑ Nishizawa, T.; Gruschow, S.; Jayamaha, D.H.; Nishizawa-Harada, C.; Sherman, D.H. (2006). "Enzymatic assembly of the bis-indole core of rebeccamycin". J. Am. Chem. Soc. 128 (3): 724–725. PMID 16417354. doi:10.1021/ja056749x.
- ↑ Howard-Jones, A.R.; Walsh, C.T. (2005). "Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD". Biochemistry. 44 (48): 15652–15663. PMID 16313168. doi:10.1021/bi051706e.
External links
- Chromopyrrolate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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