Dextran 70

Dextran 70
Clinical data
Trade names RescueFlow, others
AHFS/Drugs.com Monograph
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration		 intravenous
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
Chemical and physical data
Molar mass 70,000 kDa

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume.[1] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available. However, it does not carry oxygen.[2]

Common side effects include vomiting, fever, and joint pains.[2] Other side effects include allergic reactions and poor blood clotting.[1] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder.[2] Use is also not recommended during pregnancy.[3] It works by pulling fluid from the extravascular space into the blood vessels.[2]

Dextran 70 was approved for medical use in 1947.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] The wholesale cost in the developing world is about 4.10 to 5.25 USD per 500 ml.[6] In the United Kingdom this dose costs the NHS about 57.00 pounds.[3] In the United States it costs about 25 to 50 USD per dose.[7] It comes in either sodium chloride solution or glucose solution.[2]

References

  1. 1 2 WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Retrieved 8 December 2016.
  2. 1 2 3 4 5 "Dextran 70". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
  3. 1 2 British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.
  4. ↑ BeMiller, James N.; Whistler, Roy L. (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544.
  5. ↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
  6. ↑ "Dextran 70 6% in Sod. chloride 0.9%". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  7. ↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 167. ISBN 9781284057560.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.