Desmoglein
The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.
Pathology
Desmogleins are targeted in the autoimmune disease pemphigus.[1][2][3]
References
- ↑ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). "Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. PMC 1242188
. PMID 16211092. doi:10.1172/JCI23475. - ↑ Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell. 113 (2): 249–60. PMID 12705872. doi:10.1016/S0092-8674(03)00273-3.
- ↑ Müller R, Heber B, Hashimoto T, et al. (May 2009). "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol. 34 (8): 898–903. PMID 19456767. doi:10.1111/j.1365-2230.2009.03241.x.
External links
- Histology image: 20502loa – Histology Learning System at Boston University
- Desmogleins at the US National Library of Medicine Medical Subject Headings (MeSH)
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