Desmethoxyfallypride

Desmethoxyfallypride (18F)
Clinical data
Pregnancy
category
  • N/A
ATC code
  • none
Legal status
Legal status
  • Research compound
Identifiers
Synonyms DMFP (18F)
PubChem CID
ChemSpider
Chemical and physical data
Formula C19H27FN2O2
Molar mass 333.430818 g/mol
3D model (JSmol)

Desmethoxyfallypride is a moderate affinity dopamine D2 receptor/D3 receptor antagonist used in medical research, usually in the form of the radiopharmaceuticals desmethoxyfallypride or DMFP(18F)[1][2] and has been used in human studies[3][4] as a positron emission tomography (PET) radiotracer.

References

  1. ↑ Mukherjee, J; Yang, Z. Y.; Brown, T; Roemer, J; Cooper, M (1996). "18F-desmethoxyfallypride: A fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors". Life Sciences. 59 (8): 669–78. PMID 8761017. doi:10.1016/0024-3205(96)00348-7.
  2. ↑ Leung, K (2004). "(S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-18Ffluoropropyl)-2-methoxybenzamide". PMID 20641474.
  3. ↑ Gründer, G; Siessmeier, T; Piel, M; Vernaleken, I; Buchholz, H. G.; Zhou, Y; Hiemke, C; Wong, D. F.; Rösch, F; Bartenstein, P (2003). "Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride". Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 44 (1): 109–16. PMID 12515884.
  4. ↑ Siessmeier, T; Zhou, Y; Buchholz, H. G.; Landvogt, C; Vernaleken, I; Piel, M; Schirrmacher, R; Rösch, F; Schreckenberger, M; Wong, D. F.; Cumming, P; Gründer, G; Bartenstein, P (2005). "Parametric mapping of binding in human brain of D2 receptor ligands of different affinities". Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 46 (6): 964–72. PMID 15937307.
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