David O'Brien
David or Dave O'Brien may refer to:
Sports
- David O'Brien (footballer) (born 1984), Scottish footballer for Greenock Morton
- David O'Brien (racehorse trainer), Irish former racehorse trainer
- David O'Brien (sailor) (born 1965), Irish yacht racer
- David O'Brien (swimmer) (born 1983), English swimmer
- Dave O'Brien (athletic director) (1956–2014), American athletic director at Long Beach State, Temple University and Northeastern University
- Dave O'Brien (sportscaster) (born 1963), American sportscaster
- Davey O'Brien (1917–1977), American football quarterback
Others
- David O'Brien (actor) (1937–1989), American soap opera actor
- David O'Brien (politician) (born 1970), Australian politician
- David P. O'Brien, Canadian businessman
- Dave O'Brien (actor) (1912–1969), American film actor, director and writer
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