David Ian Stuart

David Stuart
FRS FMedSci
Born David Ian Stuart
(1953-12-08) December 8, 1953
Fields Structural Biology
Virology
Crystallography
Synchrotron radiation[1]
Institutions Wellcome Trust Centre for Human Genetics
University of Oxford
Diamond Light Source
Alma mater University of London (BSc)
University of Oxford (MA)
University of Bristol (PhD)[2]
Thesis X-ray studies on pyruvate kinase (1979)
Doctoral advisor Hilary Muirhead
Influences Louise Johnson
Notable awards Descartes Prize
Gregori Aminoff Prize
Website
www.strubi.ox.ac.uk/research/david-stuart

David Ian Stuart FRS FMedSci (born December 8, 1953) is Medical Research Council Professor of Structural Biology at the Wellcome Trust Centre for Human Genetics at the University of Oxford where he is also a Fellow of Hertford College, Oxford.[2] He is best known for his contributions to the X-ray crystallography of viruses, in particular for determining the structures of foot-and-mouth disease virus,[3] bluetongue virus and the membrane-containing phages PRD1 (the first structure of an enveloped virus) and PM2. He is also director of Instruct[4] and Life Sciences Director at Diamond Light Source.[5]

Education

Stuart was born in 1953 in Lancashire. He was educated initially in Helmshore, Lancashire, and then in North Devon, at Barnstaple Grammar School. He studied Biophysics at King's College London, graduating in 1974[2] after which he attended the University of Bristol and completed a PhD in the Biochemistry Department in 1979,[6] working on the structure of the enzyme pyruvate kinase in the laboratory of Hilary Muirhead.[2]

Career and research

Stuart moved to Oxford in 1979 and worked with Louise Johnson on the structure of the enzyme glycogen phosphorylase before moving in 1981 to work at the Institute of Biophysics in Beijing, China, with Liang Dong-Cai on insulin. Returning to Oxford in 1983 to work with Johnson he then in 1985 set up his own research group in the Laboratory of Molecular Biophysics, focused mainly on virus–receptor interactions and virus assembly. In 1999 Stuart led the establishment of the Division of Structural Biology, in the Nuffield Department of Medicine.

Stuart has solved the atomic structures of complex biological molecules and viruses, including foot-and-mouth disease virus, bluetongue virus and the membrane-containing phages PRD1 (the first structure of an enveloped virus) and PM2.[7][1][8] His structure of foot-and-mouth virus has assisted in the development of improved vaccines via structural vaccinology. He has also investigated the structure of the HIV reverse transcriptase protein, facilitating targeted drug design. Stuart also develops methods in structural biology and researches protein structure and evolution.

Since 2008 Stuart has, as life science director, helped the development of the Diamond Light Source, the UK's synchrotron light source.

Honours and awards

Stuart has received a number of awards and honours for his work on viral structure, including:

References

  1. 1 2 David Ian Stuart publications indexed by Google Scholar
  2. 1 2 3 4 STUART, Prof. David Ian. ukwhoswho.com. Who's Who. 2017 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  3. ↑ Acharya, Ravindra; Fry, Elizabeth; Stuart, David; Fox, Graham; Rowlands, David; Brown, Fred (1989). "The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution". Nature. 337 (6209): 709–716. ISSN 0028-0836. PMID 2537470. doi:10.1038/337709a0. (subscription required)
  4. ↑ "Instruct Scientists". structuralbiology.eu. Archived from the original on 2016-11-11.
  5. ↑ "David Stuart". ox.ac.uk. Archived from the original on 2016-11-11.
  6. ↑ Stuart, David Ian (1979). X-ray studies on pyruvate kinase. exlibrisgroup.com (PhD thesis). University of Bristol.
  7. ↑ David Ian Stuart publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  8. ↑ David Ian Stuart publications from Europe PubMed Central
  9. 1 2 3 Anon (1994). "David Stuart". royalsociety.org. Royal Society. Archived from the original on 14 November 2016. Retrieved 14 November 2016.
  10. ↑ "Max Perutz prize awarded to David Stuart". ecanews.org. Archived from the original on 2016-11-12.
  11. ↑ "University
 of 
Helsinki: Honorary 
doctors 
of 
the 
Faculty 
of 
Philosophy" (PDF). helsinki.fi. Archived from the original (PDF) on 2016-08-04.
  12. ↑ "Award-winning musician among those honoured by the University". leeds.ac.uk. Archived from the original on 2016-12-20.
  13. ↑ "Professor David Stuart, FRS: Doctor of Science". bristol.ac.uk. Archived from the original on 2016-11-11.
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