David Ballou

David P. Ballou
Citizenship American
Nationality American
Fields Biochemistry
Institutions University of Michigan
Alma mater Antioch College
University of Michigan
Thesis  (1971)
Doctoral advisor Graham Palmer
Other academic advisors Vince Massey
Minor J. Coon
Known for Presteady-state enzyme kinetics methods
Spouse Jean Ballou[1]

David P. Ballou is a professor of biological chemistry at the University of Michigan Medical School in the United States.[1] He is best known for his development of rapid-reaction techniques,[2] including stopped flow and rapid freeze-quench EPR methods,[3] as tools to study the mechanisms of enzymes containing flavin,[4] iron,[5] cobalamin, or pyridoxal phosphate cofactors. Many of these studies were performed in collaboration with other scientists, most often with colleagues at Michigan.[6]

Biography

David Ballou grew up in Connecticut.[2] He received a B.S. in chemistry from Antioch College in 1965. In 1971, he received a Ph.D. from the University of Michigan under the supervision of Graham Palmer. From 1971-1972, he was a postdoctoral fellow with Vincent Massey and Minor J. Coon at the University of Michigan. He has been a faculty member in the Department of Biological Chemistry at the University of Michigan Medical School since 1972. In 2007, Ballou became a Fellow of the American Association for the Advancement of Science in recognition of his discovery of enzyme intermediates that are involved in biological oxidation reactions.[7] His most cited paper, l, "Oxidative Protein Folding Is Driven by the Electron Transport System",[8] has been cited 311 times according to Google Scholar, and he has contributed to 25 papers having more than 0100 citations each.[9]

Books

References

  1. 1 2 "David Ballou, Ph.D.". Retrieved 2013-10-27.
  2. 1 2 Cheng Z, Zhang J, Ballou DP, Williams CH Jr (2011). "Reactivity of Thioredoxin as a Protein Thiol-Disulfide Oxidoreductase". Chemical Reviews. 111 (9): 5768–5783. PMC 3212873 Freely accessible. PMID 21793530. doi:10.1021/cr100006x.
  3. ↑ Ballou DP, Palmer GA (1974). "Practical rapid quenching instrument for the study of reaction mechanisms by electron paramagnetic resonance spectroscopy". Analytical Chemistry. 46 (9): 1248–1253. doi:10.1021/ac60345a034.
  4. ↑ Ballou DP, Entsch B, Cole LJ (2005). "Dynamics involved in catalysis by single-component and two-component flavin-dependent aromatic hydroxylases". Biochem. Biophys. Res. Commun. 338 (1): 590–598. PMID 16236251. doi:10.1016/j.bbrc.2005.09.081.
  5. ↑ Gassner GT, Ludwig ML, Gatti DL, Correll CC, Ballou DP (1995). "Structure and mechanism of the iron-sulfur flavoprotein phthalate dioxygenase reductase". FASEB Journal. 9 (14): 1411–1418. PMID 7589982.
  6. ↑ "DP Ballou at Pubmed". Retrieved 2013-10-31.
  7. ↑ "AAAS Welcomes Two from Medical School". Retrieved 2013-10-27.
  8. ↑ Martin Bader, Wilson Muse, David P Ballou, Christian Gassner, James C.A Bardwell, "Oxidative Protein Folding Is Driven by the Electron Transport System", published in Cell Volume 98, Issue 2, p217–227, 23 July 1999
  9. ↑
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