DOK3

DOK3

Identifiers

DOK3, DOKL, docking protein 3

External IDs

MGI: 1351490 HomoloGene: 8448 GeneCards: DOK3

Gene ontology
Molecular function	• insulin receptor binding • protein binding
Cellular component	• membrane • cytoplasm • plasma membrane • secretory granule membrane • ficolin-1-rich granule membrane
Biological process	• neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


79930


27261


ENSG00000146094


ENSMUSG00000035711


Q7L591


Q9QZK7

RefSeq (mRNA)


NM_001144875 NM_001144876 NM_001308235 NM_001308236 NM_024872


NM_013739

RefSeq (protein)


NP_001138347 NP_001138348 NP_001295164 NP_001295165 NP_079148


NP_038767

Location (UCSC)

Chr 5: 177.5 – 177.51 Mb

Chr 13: 55.52 – 55.53 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol. 20 (8): 2743–54. PMC 85490 . PMID 10733577. doi:10.1128/MCB.20.8.2743-2754.2000.
↑ Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. PMID 12595900. doi:10.1038/sj.gene.6363891.
↑ "Entrez Gene: DOK3 docking protein 3".

Further reading

Cong F, Yuan B, Goff SP (2000). "Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling". Mol. Cell. Biol. 19 (12): 8314–25. PMC 84915 . PMID 10567556.
Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J. Cell Biol. 154 (2): 345–54. PMC 2150770 . PMID 11470823. doi:10.1083/jcb.200102032.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Robson JD, Davidson D, Veillette A (2004). "Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3". Mol. Cell. Biol. 24 (6): 2332–43. PMC 355862 . PMID 14993273. doi:10.1128/MCB.24.6.2332-2343.2004.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Honma M, Higuchi O, Shirakata M, et al. (2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases". Genes Cells. 11 (2): 143–51. PMID 16436051. doi:10.1111/j.1365-2443.2006.00926.x.

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