DOK2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2D9W, 2DLW

Identifiers

Aliases

DOK2, p56DOK, p56dok-2, docking protein 2

External IDs

MGI: 1332623 HomoloGene: 2957 GeneCards: DOK2

Gene ontology
Molecular function	• signal transducer activity, downstream of receptor • protein binding • transmembrane receptor protein tyrosine kinase adaptor activity • insulin receptor binding
Cellular component	• cytosol
Biological process	• cell surface receptor signaling pathway • Ras protein signal transduction • leukocyte migration • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • axon guidance
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9046


13449

Ensembl


ENSG00000147443


ENSMUSG00000022102

UniProt


O60496


O70469

RefSeq (mRNA)


NM_003974 NM_201349 NM_001317800


NM_010071

RefSeq (protein)


NP_001304729 NP_003965 NP_958728


NP_034201

Location (UCSC)

Chr 8: 21.91 – 21.91 Mb

Chr 14: 70.77 – 70.78 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.^[3]^[4]^[5]

Function

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.^[5]

Interactions

DOK2 has been shown to interact with INPP5D^[6] and TEK tyrosine kinase.^[7]^[8]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD (March 1998). "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins". J Biol Chem. 273 (9): 4827–30. PMID 9478921. doi:10.1074/jbc.273.9.4827.
↑ Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (March 2004). "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood. 103 (6): 2088–95. PMID 14645010. doi:10.1182/blood-2003-07-2392.
1 2 "Entrez Gene: DOK2 docking protein 2, 56kDa".
↑ Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. PMID 10822173. doi:10.1016/S0898-6568(00)00073-5.
↑ Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. PMID 9764820. doi:10.1038/sj.onc.1202115.
↑ Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. PMC 125712 . PMID 11689432. doi:10.1093/emboj/20.21.5919.

Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. PMID 10856136. doi:10.1067/mai.2000.107604.
Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.". Oncogene. 17 (9): 1097–108. PMID 9764820. doi:10.1038/sj.onc.1202115.
Jones N, Dumont DJ (2000). "Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation.". Curr. Biol. 9 (18): 1057–60. PMID 10508618. doi:10.1016/S0960-9822(99)80458-8.
Némorin JG, Duplay P (2000). "Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.". J. Biol. Chem. 275 (19): 14590–7. PMID 10799545. doi:10.1074/jbc.275.19.14590.
Dunant NM, Wisniewski D, Strife A, et al. (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.". Cell. Signal. 12 (5): 317–26. PMID 10822173. doi:10.1016/S0898-6568(00)00073-5.
Némorin JG, Laporte P, Bérubé G, Duplay P (2001). "p62dok negatively regulates CD2 signaling in Jurkat cells.". J. Immunol. 166 (7): 4408–15. PMID 11254695. doi:10.4049/jimmunol.166.7.4408.
Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.". J. Cell Biol. 154 (2): 345–54. PMC 2150770 . PMID 11470823. doi:10.1083/jcb.200102032.
Master Z, Jones N, Tran J, et al. (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.". EMBO J. 20 (21): 5919–28. PMC 125712 . PMID 11689432. doi:10.1093/emboj/20.21.5919.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Salomon AR, Ficarro SB, Brill LM, et al. (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. PMC 141014 . PMID 12522270. doi:10.1073/pnas.2436191100.
Jones N, Chen SH, Sturk C, et al. (2003). "A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function.". Mol. Cell. Biol. 23 (8): 2658–68. PMC 152553 . PMID 12665569. doi:10.1128/MCB.23.8.2658-2668.2003.
Master Z, Tran J, Bishnoi A, et al. (2003). "Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization.". J. Biol. Chem. 278 (32): 30170–9. PMID 12777393. doi:10.1074/jbc.M301339200.
Gérard A, Favre C, Garçon F, et al. (2004). "Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase.". Oncogene. 23 (8): 1594–8. PMID 14647425. doi:10.1038/sj.onc.1207283.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. PMID 15144186. doi:10.1021/ac035352d.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. PMID 15592455. doi:10.1038/nbt1046.
Van Slyke P, Coll ML, Master Z, et al. (2005). "Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.". Mol. Cell. Biol. 25 (9): 3831–41. PMC 1084282 . PMID 15831486. doi:10.1128/MCB.25.9.3831-3841.2005.

PDB gallery

2d9w: Solution structure of the PH domain of Docking protein 2 from human

2dlw: Solution structure of the IRS domain of human docking protein 2, isoform a

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DOK2

Function

Interactions

References

Further reading