DOCK (protein)
| Dedicator of cytokinesis | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Ded_cyto | ||||||||
| Pfam | PF06920 | ||||||||
| InterPro | IPR010703 | ||||||||
| SCOP | 1wg7 | ||||||||
| SUPERFAMILY | 1wg7 | ||||||||
| CDD | cd11684 | ||||||||
| |||||||||
DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.[1] Studies to date suggest that this family act as guanine nucleotide exchange factors for small G proteins of the Rho family, such as Rac and Cdc42. DOCK family proteins are categorised into four subfamilies based on their sequence homology:
- DOCK-A subfamily
- DOCK-B subfamily
- DOCK-C subfamily (also known as Zir subfamily)
- DOCK-D subfamily (also known as Zizimin subfamily)
References
- ↑ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell. Sci. 115 (Pt 24): 4901–13. PMID 12432077. doi:10.1242/jcs.00219.
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