DNA topoisomerase
| DNA topoisomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.99.1.2 | ||||||||
| CAS number | 80449-01-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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DNA topoisomerase (EC 5.99.1.2, type I DNA topoisomerase, untwisting enzyme, relaxing enzyme, nicking-closing enzyme, swivelase, omega-protein, deoxyribonucleate topoisomerase) is an enzyme with systematic name DNA topoisomerase.[1] This enzyme catalyses the following chemical reaction
- ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
These enzymes bring about the conversion of one topological isomer of DNA into another. There are two types of DNA topoisomerase; I and II. Both of which are further classified into sub families IA, IB, IIA, and IIB. DNA topoisomerase facilitates a transesterification reaction. Through this reaction DNA topoisomerase is able to break and rejoin the phosphate backbone of DNA. [2]
References
- ↑ Gellert M (1981). "DNA topoisomerases". Annual Review of Biochemistry. 50: 879–910. PMID 6267993. doi:10.1146/annurev.bi.50.070181.004311.
- ↑ Wang JC (June 2002). "Cellular roles of DNA topoisomerases: a molecular perspective". Nature Reviews. Molecular Cell Biology. 3 (6): 430–40. PMID 12042765. doi:10.1038/nrm831.
See also
External links
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Wikimedia Commons has media related to DNA topoisomerases. |
- DNA topoisomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
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