DHX15

DHX15

Identifiers

DHX15, DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p, DEAH-box helicase 15

External IDs

MGI: 1099786 HomoloGene: 1040 GeneCards: DHX15

Gene ontology
Molecular function	• RNA helicase activity • nucleotide binding • double-stranded RNA binding • ATP-dependent RNA helicase activity • protein binding • ATP binding • helicase activity • hydrolase activity • nucleic acid binding • RNA binding
Cellular component	• U12-type spliceosomal complex • nucleolus • U2-type post-mRNA release spliceosomal complex • cytoplasm • nucleus • nucleoplasm • nuclear speck
Biological process	• mRNA processing • response to alkaloid • response to toxic substance • RNA splicing • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


1665


13204


ENSG00000109606


ENSMUSG00000029169


O43143


O35286

RefSeq (mRNA)


NM_001358


NM_001042620 NM_007839

RefSeq (protein)


NP_001349


NP_001036085 NP_031865

Location (UCSC)

Chr 4: 24.52 – 24.58 Mb

Chr 5: 52.15 – 52.19 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.^[3]^[4]

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. PMID 9388478. doi:10.1006/bbrc.1997.7585.
1 2 "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".

Further reading

Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. PMID 9747670. doi:10.1080/10409239891204233.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. PMC 1370585 . PMID 15146077. doi:10.1261/rna.7320604.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase". RNA. 8 (11): 1428–43. PMC 1370349 . PMID 12458796. doi:10.1017/S1355838202021076.
Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22". Mol. Cell. Biol. 14 (11): 7611–20. PMC 359297 . PMID 7935475.

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