DGKQ

DGKQ
Identifiers
Aliases	DGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta
External IDs	MGI: 102918 HomoloGene: 20352 GeneCards: DGKQ
Gene ontology Molecular function • transferase activity • nucleotide binding • phospholipase binding • activating transcription factor binding • metal ion binding • kinase activity • kinase binding • protein binding • ATP binding • diacylglycerol kinase activity • transmembrane receptor protein tyrosine kinase activator activity • NAD+ kinase activity Cellular component • cytoplasm • cytosol • nuclear speck • membrane • plasma membrane • cytoskeleton • nucleus • endosome • vesicle membrane • nuclear matrix Biological process • G-protein coupled receptor signaling pathway • thrombin-activated receptor signaling pathway • response to ATP • intracellular signal transduction • phosphorylation • regulation of transcription from RNA polymerase II promoter • protein kinase C signaling • platelet activation • protein kinase C-activating G-protein coupled receptor signaling pathway • signal transduction • glycerolipid metabolic process • diacylglycerol metabolic process • lipid phosphorylation • regulation of gluconeogenesis • phosphatidic acid biosynthetic process • activation of transmembrane receptor protein tyrosine kinase activity • regulation of G-protein coupled receptor protein signaling pathway • positive regulation of gene expression • negative regulation of gene expression • negative regulation of peptidyl-threonine phosphorylation • peptidyl-serine phosphorylation • cAMP-mediated signaling • positive regulation of peptidyl-tyrosine phosphorylation • response to cAMP • regulation of cholesterol metabolic process • regulation of TORC1 signaling • regulation of cortisol biosynthetic process • regulation of progesterone biosynthetic process • metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1609	110524
Ensembl	ENSG00000145214	ENSMUSG00000004815
UniProt	P52824	Q6P5E8
RefSeq (mRNA)	NM_001347	NM_199011
RefSeq (protein)	NP_001338	NP_950176
Location (UCSC)	Chr 4: 0.96 – 0.99 Mb	Chr 5: 108.65 – 108.67 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.^[3][4][5]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.^[5]

Interactions

DGKQ has been shown to interact with RHOA.^[6]

References

Further reading