DEFB105A
| DEFB105A | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | DEFB105A, BD-5, DEFB-5, DEFB105, defensin beta 105A | ||||||
| External IDs | MGI: 1924924 HomoloGene: 17531 GeneCards: DEFB105A | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez | |||||||
| Ensembl | |||||||
| UniProt | |||||||
| RefSeq (mRNA) | |||||||
| RefSeq (protein) | |||||||
| Location (UCSC) | Chr 8: 7.82 – 7.82 Mb | Chr 8: 19.11 – 19.11 Mb | |||||
| PubMed search | [1] | [2] | |||||
| Wikidata | |||||||
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Beta-defensin 105 is a protein that in humans is encoded by the DEFB105A gene.[3][4][5]
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. PMC 122330
. PMID 11854508. doi:10.1073/pnas.042692699. - ↑ Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. PMC 156587 . PMID 12734011. doi:10.1186/gb-2003-4-5-r31.
- 1 2 "Entrez Gene: DEFB105A defensin, beta 105A".
Further reading
- Patil AA, Cai Y, Sang Y, et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.". Physiol. Genomics. 23 (1): 5–17. PMID 16033865. doi:10.1152/physiolgenomics.00104.2005.
- Boniotto M, Ventura M, Eskdale J, et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.". Genet. Test. 8 (3): 325–7. PMID 15727258. doi:10.1089/gte.2004.8.325.
- Taudien S, Galgoczy P, Huse K, et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.". BMC Genomics. 5 (1): 92. PMC 544879 . PMID 15588320. doi:10.1186/1471-2164-5-92.
- Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.". Am. J. Hum. Genet. 73 (3): 591–600. PMC 1180683 . PMID 12916016. doi:10.1086/378157.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Yamaguchi Y, Nagase T, Makita R, et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.". J. Immunol. 169 (5): 2516–23. PMID 12193721. doi:10.4049/jimmunol.169.5.2516.
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