DAPP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FAO, 1FB8

Identifiers

Aliases

DAPP1, BAM32, dual adaptor of phosphotyrosine and 3-phosphoinositides, dual adaptor of phosphotyrosine and 3-phosphoinositides 1

External IDs

MGI: 1347063 HomoloGene: 32138 GeneCards: DAPP1

Gene ontology
Molecular function	• protein binding • phospholipid binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding • PDZ domain binding
Cellular component	• cytosol • plasma membrane • membrane • cytoplasm
Biological process	• protein dephosphorylation • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


27071


26377

Ensembl


ENSG00000070190


ENSMUSG00000028159

UniProt


Q9UN19


Q9QXT1

RefSeq (mRNA)


NM_001306151 NM_014395


NM_011932 NM_001310753

RefSeq (protein)


NP_001293080 NP_055210


NP_001297682 NP_036062

Location (UCSC)

Chr 4: 99.82 – 99.87 Mb

Chr 3: 137.93 – 137.98 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Dowler S, Currie RA, Downes CP, Alessi DR (Oct 1999). "DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides". Biochem J. 342 (1): 7–12. PMC 1220429 . PMID 10432293. doi:10.1042/0264-6021:3420007.
↑ "Entrez Gene: DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Marshall AJ, Niiro H, Lerner CG, et al. (2000). "A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.". J. Exp. Med. 191 (8): 1319–32. PMC 2193139 . PMID 10770799. doi:10.1084/jem.191.8.1319.
Dowler S, Montalvo L, Cantrell D, et al. (2001). "Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.". Biochem. J. 349 (Pt 2): 605–10. PMC 1221184 . PMID 10880360. doi:10.1042/0264-6021:3490605.
Ferguson KM, Kavran JM, Sankaran VG, et al. (2000). "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.". Mol. Cell. 6 (2): 373–84. PMID 10983984. doi:10.1016/S1097-2765(00)00037-X.
Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.". Biochem. J. 351 (Pt 1): 19–31. PMC 1221362 . PMID 11001876. doi:10.1042/0264-6021:3510019.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMC 310934 . PMID 11042152. doi:10.1101/gr.140200.
Stephens LR, Anderson KE, Hawkins PT (2001). "Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines.". J. Biol. Chem. 276 (46): 42767–73. PMID 11524430. doi:10.1074/jbc.M107194200.
Niiro H, Maeda A, Kurosaki T, Clark EA (2002). "The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival.". J. Exp. Med. 195 (1): 143–9. PMC 2196019 . PMID 11781373. doi:10.1084/jem.20011524.
Marshall AJ, Krahn AK, Ma K, et al. (2002). "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor.". Mol. Cell. Biol. 22 (15): 5479–91. PMC 133950 . PMID 12101241. doi:10.1128/MCB.22.15.5479-5491.2002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Han A, Saijo K, Mecklenbräuker I, et al. (2003). "Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival.". Immunity. 19 (4): 621–32. PMID 14563325. doi:10.1016/S1074-7613(03)00275-9.
Allam A, Niiro H, Clark EA, Marshall AJ (2004). "The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism.". J. Biol. Chem. 279 (38): 39775–82. PMID 15247305. doi:10.1074/jbc.M403367200.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Niiro H, Allam A, Stoddart A, et al. (2004). "The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization.". J. Immunol. 173 (9): 5601–9. PMID 15494510. doi:10.4049/jimmunol.173.9.5601.

PDB gallery

1fao: STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE

1fb8: STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

DAPP1

References

Further reading