D-chiro-Inositol
Names | |
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IUPAC name
cis-1,2,4-trans-3,5,6 | |
Other names
DCI 1,2,4/3,5,6-Hexahydroxycyclohexane | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.010.359 |
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Properties | |
C6H12O6 | |
Molar mass | 180.16 g·mol−1 |
Melting point | 230 °C (446 °F; 503 K) |
Chiral rotation ([α]D) |
[α]23/D +55°, c = 1.2 in H2O |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
D-chiro-Inositol (commonly abbreviated DCI) is a member of a family of related substances often referred to collectively as "inositol," although that term encompasses several isomers of questionable biological relevance. It is known to be an important secondary messenger in insulin signal transduction. D-chiro-Inositol accelerates the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, rate limiting enzymes of non-oxidative and oxidative glucose disposal. D-chiro-inositol may act to bypass defective normal epimerization of myo-inositol to D-chiro-inositol associated with insulin resistance and at least partially restore insulin sensitivity and glucose disposal.[2]
References
- ↑ Merck Index, 11th Edition, 4883
- ↑ Larner, Joseph (2002). "D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance". International Journal of Experimental Diabetes Research. 3 (1): 47–60. ISSN 1560-4284. PMC 2478565 . PMID 11900279. doi:10.1080/15604280212528.
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