Cyclin-dependent kinase inhibitor protein

Cyclin-dependent kinase inhibitor

Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1]
Identifiers
Symbol CDI
Pfam PF02234
InterPro IPR003175
SCOP 1jsu
SUPERFAMILY 1jsu

A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor suppressor proteins. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G1 phase.

Examples

Protein Gene Interacts with
p16CDKN2ACyclin-dependent kinase 4, Cyclin-dependent kinase 6
p15CDKN2BCyclin-dependent kinase 4
p18CDKN2CCyclin-dependent kinase 4, Cyclin-dependent kinase 6
p19CDKN2DCyclin-dependent kinase 4, Cyclin-dependent kinase 6
p21 / WAF1CDKN1A[2]Cyclin E1/Cyclin-dependent kinase 2
p27CDKN1BCyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2
p57CDKN1CCyclin E1/Cyclin-dependent kinase 2
CDKN3Cyclin-dependent kinase 2

References

  1. Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. PMID 8684460. doi:10.1038/382325a0.
  2. Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. PMID 9989833. doi:10.1038/sj.onc.1202367.


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