Cyclin-dependent kinase 7

CDK7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UA2
Identifiers
Aliases	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, CAK, cyclin-dependent kinase 7, cyclin dependent kinase 7
External IDs	MGI: 102956 HomoloGene: 1363 GeneCards: CDK7
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • DNA-dependent ATPase activity • transcription coactivator activity • protein C-terminus binding • protein binding • androgen receptor binding • RNA polymerase II carboxy-terminal domain kinase activity • ATP binding • kinase activity • protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase activity Cellular component • nucleoplasm • holo TFIIH complex • perinuclear region of cytoplasm • nucleus • cytoplasm • TFIIK complex • cyclin-dependent protein kinase activating kinase holoenzyme complex Biological process • termination of RNA polymerase I transcription • androgen receptor signaling pathway • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of transcription, DNA-templated • phosphorylation • transcription initiation from RNA polymerase I promoter • G1/S transition of mitotic cell cycle • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • transcription, DNA-templated • cellular response to DNA damage stimulus • cell division • positive regulation of transcription, DNA-templated • protein phosphorylation • transcription elongation from RNA polymerase I promoter • G2/M transition of mitotic cell cycle • cell cycle arrest • cell cycle • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • cell proliferation • positive regulation of transcription from RNA polymerase II promoter • snRNA transcription from RNA polymerase II promoter • nucleotide-excision repair, preincision complex assembly • DNA repair • protein stabilization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1022	12572
Ensembl	ENSG00000134058 ENSG00000277273	ENSMUSG00000069089
UniProt	P50613	Q03147
RefSeq (mRNA)	NM_001799 NM_001324069 NM_001324070 NM_001324071 NM_001324072 NM_001324074 NM_001324075 NM_001324077 NM_001324078	NM_009874
RefSeq (protein)	NP_001310998 NP_001310999 NP_001311000 NP_001311001 NP_001311003 NP_001311004 NP_001311006 NP_001311007 NP_001790	NP_034004
Location (UCSC)	Chr 5: 69.23 – 69.28 Mb	Chr 13: 100.7 – 100.73 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.^[3]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.^[4]

Interactions

Cyclin-dependent kinase 7 has been shown to interact with:

See also

• Cyclin-dependent kinase
• CDK7 pathway

References

Further reading

External links

• CDK7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CDK7 human gene location in the UCSC Genome Browser.
• CDK7 human gene details in the UCSC Genome Browser.

PDB gallery
1ua2: Crystal Structure of Human CDK7