Tectitethya crypta
| Tectitethya crypta | |
|---|---|
| Scientific classification | |
| Kingdom: | Animalia |
| Phylum: | Porifera |
| Class: | Demospongiae |
| Order: | Hadromerida |
| Family: | Tethyidae |
| Genus: | Tectitethya |
| Species: | T. crypta |
| Binomial name | |
| Tectitethya crypta (de Laubenfels, 1949) | |
| Synonyms[1] | |
|
Cryptotethya crypta de Laubenfels, 1949 | |
Tectitethya crypta (formerly known as Cryptotethya crypta and Tethya crypta) is a species of demosponge belonging to the family Tethyidae.[1] It is a massive, shallow-water sponge found in the Caribbean Sea.[2][3] Oftentimes, it is covered in sand and algae.[2][3]
The nucleosides spongothymidine and spongouridine were isolated from this sponge, providing the basis for anti-viral drugs and anti-cancer drugs.[2][3] Vidarabine, an antiviral drug, was derived from these compounds.[4] The discovery of these nucleosides also led to the development of cytarabine for clinical use in the treatment of leukemia and lymphoma.[5] Gemcitabine, a fluorinated derivative of cytarabine, is used to treat pancreatic, breast, bladder, and non-small-cell lung cancer.[5]
References
- 1 2 van Soest, R. (2008). R. W. M. Van Soest, N. Boury-Esnault, J. N. A. Hooper, K. Rützler, N. J. de Voogd, B. Alvarez de Glasby, E. Hajdu, A. B. Pisera, R. Manconi, C. Schoenberg, D. Janussen, K. R. Tabachnick, M. Klautau, B. Picton, M. Kelly & J. Vacelet, eds. "Tectitethya crypta (de Laubenfels, 1949)". World Porifera database. World Register of Marine Species. Retrieved 8 April 2017.
- 1 2 3 Cerrano, Carlo; Pansini, Maurizio; Valisano, Laura; Calcinai, Barbara; Sarà, Michele; Bavestrello, Giorgio (2004). "Lagoon sponges from Carrie Bow Cay (Belize): Ecological benefits of selective sediment incorporation". Bollettino dei Musei e degli Istituti Biologici dell'Università di Genova. 68: 239–252. Retrieved 23 June 2012.
- 1 2 3 Patricia R. Bergquist (1978). Sponges. University of California Press. p. 205. ISBN 978-0-520-03658-1. Retrieved 23 June 2012.
- ↑ Sagar, Sunil; Kaur, Mandeep; Minneman, Kenneth P. (2010). "Antiviral lead compounds from marine sponges". Marine Drugs. 8 (10): 2619–2638. PMC 2992996
. PMID 21116410. doi:10.3390/md8102619. - 1 2 Schwartsmann, G; Brondani da Rocha, A; Berlinck, RG; Jimeno, J (April 2001). "Marine organisms as a source of new anticancer agents". Lancet Oncology. 2 (4): 221–225. PMID 11905767. doi:10.1016/s1470-2045(00)00292-8.