Conserved oligomeric Golgi complex
The Conserved oligomeric Golgi complex (COG) is a multiprotein complex found in the Golgi apparatus structure and involved in intracellular transport and glycoprotein modification.[1]
Earlier names for this complex were : the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex (Ungar et al., 2002).[supplied by OMIM][2]
- Structure
The COG protein complex consists of eight subunits, in two lobes; Lobe A consists of COG1, COG2, COG3, COG4 and lobe B consists of COG5, COG6, COG7, COG8.[3]
Further reading
- Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith & Lupashin. 2008
- The conserved oligomeric Golgi complex is required for fucosylation of N-glycans in Caenorhabditis elegans. 2012 See Introduction
References
- ↑ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. PMC 2173297
. PMID 11980916. doi:10.1083/jcb.200202016. - ↑ "Entrez Gene: COG5 component of oligomeric golgi complex 5".
- ↑ Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith & Lupashin. 2008
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