Clefamide

Clefamide
Clinical data

Trade names	Mebinol
ATC code	P01AC02 (WHO)
Identifiers
IUPAC name 2,2-Dichloro-N-(2-hydroxyethyl)-N-[[4-(4-nitrophenoxy)phenyl]methyl]
CAS Number	3576-64-5
PubChem CID	71819
ChemSpider	64843^Y
UNII	4AZ2V8K4EK
KEGG	D07354^Y
ChEMBL	CHEMBL1788400
ECHA InfoCard	100.020.631
Chemical and physical data
Formula	C₁₇H₁₆Cl₂N₂O₅
Molar mass	399.23 g/mol
3D model (JSmol)	Interactive image
SMILES ClC(Cl)C(=O)N(CCO)Cc2ccc(Oc1ccc(cc1)[N+]([O-])=O)cc2
InChI InChI=1S/C17H16Cl2N2O5/c18-16(19)17(23)20(9-10-22)11-12-1-5-14(6-2-12)26-15-7-3-13(4-8-15)21(24)25/h1-8,16,22H,9-11H2^Y Key:ODCUSWJXZDHLKV-UHFFFAOYSA-N^Y
(verify)

Clefamide (trade name Mebinol) is an antiprotozoal agent that was used to treat amoebiasis in the 1960s.^[1] There is no evidence for any later use of the drug.

References

↑ Rodrigues, L. D.; Jafferian, P. A.; Vilella Mde, P.; Costa, A. A.; De Mello, E. B. (1968). "Comparative study on 3 amebicides: Teclozine, clefamide and a combination of clefamide and iodo-chloro-oxyquinolines and streptomycin". Hospital (Rio de Janeiro, Brazil). 74 (5): 1563–1573. PMID 5305335.

Antiparasitics – antiprotozoal agents – agents against amoebozoa/amebicide (P01)

Entamoeba

Tissue amebicides

Nitroimidazole derivatives	Metronidazole^# Tinidazole Ornidazole Nimorazole Secnidazole Azanidazole Propenidazole
Other	isoquinoline (Emetine/Dehydroemetine)

Luminal amebicides

Hydroxyquinoline derivatives	Cl (Chlorquinaldol) Br (Tilbroquinol Broxyquinoline) I (Diiodohydroxyquinoline) I, Cl (Clioquinol) related: Chiniofon
Dichloroacetamide derivatives	Diloxanide^# Clefamide Etofamide Teclozan
Aminoglycoside	Paromomycin

Other/ungrouped

Acanthamoeba

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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