Class C GPCR
| 7 transmembrane receptor (metabotropic glutamate family) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | 7tm_3 | ||||||||
| Pfam | PF00003 | ||||||||
| InterPro | IPR000337 | ||||||||
| PROSITE | PDOC00754 | ||||||||
| TCDB | 9.A.14 | ||||||||
| OPM superfamily | 6 | ||||||||
| OPM protein | 4or2 | ||||||||
| |||||||||
The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterPro: IPR000162) and several additional receptors.[1]
Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length PMID 17266540. This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.
Subfamilies
Calcium-sensing receptor-related
GABAB receptors
- GABAB receptor (gamma-aminobutyric acid) InterPro: IPR002455
Metabotropic glutamate receptors
RAIG
Taste receptors
Orphan
Other
- Bride of sevenless protein InterPro: IPR002956
- Vomeronasal receptor, type 2 InterPro: IPR004073
References
- ↑ Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets. 8 (1): 169–84. PMID 17266540. doi:10.2174/138945007779315614.