Chymopapain

Chymopapain

Chymopapain's structure
Identifiers
EC number 3.4.22.6
CAS number 2593837
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Chymopapain
Clinical data
Routes of
administration
Injection into intervertebral disc
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
ChemSpider
  • none
UNII
ChEMBL
 NYesY (what is this?)  (verify)

Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a medication used to treat herniated lower lumbar discs in the spine.[1] Chymopapain injections are normally given under local, rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals. The procedure is referred to as chemonucleolysis.

The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003 after the company producing it decided to stop selling worldwide.[2][3]

Side effects

Serious side effects from the use of chymopapain include anaphylaxis, paralysis of the legs, or death.[4]

See also

References

  1. Chymopapain Injection from MedicineNet
  2. http://www.mayoclinic.com/health/drug-information/DR600373
  3. The Current Status of Chymopapain
  4. http://www.mayoclinic.com/health/drug-information/DR600373
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