Chrysophanic acid
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| Names | |
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| IUPAC name
1,8-Dihydroxy-3-methyl-9,10-anthraquinone | |
| Identifiers | |
| 3D model (JSmol) |
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| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.006.885 |
| PubChem CID |
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| Properties | |
| C15H10O4 | |
| Molar mass | 254.24 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Chrysophanic acid, also known as chrysophanol, is a fungal isolate and a natural anthraquinone. It blocks the proliferation of colon cancer cells in vitro.[1]
Mechanism of action
Chrysophanol induces the necrosis of cancer cells via a reduction in ATP levels.[2] Chrysophanol attentuates the effects of lead exposure in mice by reducing hippocampal neuronal cytoplasmic edema, enhancing mitochondrial crista fusion, significantly increasing memory and learning abilities, reducing lead content in blood, heart, brain, spleen, kidney and liver, promoting superoxide dismutase and glutathione peroxidase activities and reducing malondialdehyde level in the brain, kidney and liver.[3]
References
- ↑ Lee, MS; Cha, EY; Sul, JY; Song, IS; Kim, JY (2011). "Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway". Phytotherapy research : PTR. 25 (6): 833–7. PMID 21089180. doi:10.1002/ptr.3323.
- ↑ Burnstock, G; Di Virgilio, F (Dec 2013). "Purinergic signalling and cancer.". Purinergic Signalling (journal). 9 (4): 491–540. PMC 3889385
. PMID 23797685. doi:10.1007/s11302-013-9372-5. - ↑ Ji Zhang, Chunlin Yan, Shu Wang, Yong Hou, Guiping Xue, Li Zhang (2014). "Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice". Neural Regeneration Research. 9 (9): 924–930.
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